Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE There was no interaction between depression and Val66Met genotype status. 25188405

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found. 23684538

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects. 23968401

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. 23880378

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity. 23733090

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke. 23399480

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. 23481907

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB. 24274373

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. 22931410

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. 22883353

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression. 22033217

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. 22610920

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met genotype and 6-month remission rates in late-life depression. 20195291

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. 20667416

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction). 21880305

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD). 21692988

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. 21420735

2011

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025). 20515362

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. 20346518

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression. 20728877

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders. 20515664

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. 21037213

2010