Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132

2020

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132

2020

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression. 30664620

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF. 29280414

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT. 29802070

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population. 29535036

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC. 30904785

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF. 29280414

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population. 29535036

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC. 30904785

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT. 29802070

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect. 29102837

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet. 29734099

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Further studies are needed to evaluate the associations between rs6265 and poststroke depression, especially in Caucasians, with large sample size. 29449128

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression. 29331787

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet. 29734099

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect. 29102837

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression. 29331787

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Present meta-analysis supports that there is a meager significant association between MTHFR C677T polymorphism and depression risk. 28968218

2017

dbSNP: rs25531
rs25531
0.100 GeneticVariation BEFREE Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese. 27788383

2017

dbSNP: rs25531
rs25531
0.100 GeneticVariation BEFREE Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures. 28024274

2017

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE We concluded that depression and COMT rs4680 "GG" and "GA" genotypes and COMT rs6267 "GT" genotype contribute to pain in PD patients. 28740224

2017

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. 28416295

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission. 27409526

2017