| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.080 | GeneticVariation | BEFREE | Clinical association to FKBP5 rs1360780 in patients with depression. | 31219960 | 2019 |
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0.080 | GeneticVariation | BEFREE | The significant interaction between ELA and the rs1360780 polymorphism in HATA suggests a role of FKBP5 in the pathophysiology of structural alterations in depression. | 30986730 | 2019 |
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0.080 | GeneticVariation | BEFREE | Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population. | 29535036 | 2019 |
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0.080 | GeneticVariation | BEFREE | Third, there is an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk. | 26801675 | 2017 |
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0.080 | GeneticVariation | BEFREE | The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after psychosocial stress in healthy controls but not in remitted depression. | 25522420 | 2014 |
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0.080 | GeneticVariation | BEFREE | To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. | 23157339 | 2013 |
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0.080 | GeneticVariation | BEFREE | Given the large effect sizes, rs1360780 could be included into prediction models for depression in individuals exposed to childhood abuse. | 21654733 | 2011 |
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0.080 | GeneticVariation | BEFREE | FKBP5:rs1360780 allele T and genotype TT were overrepresented in depression for men. | 20226536 | 2010 |