Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5522
rs5522
NR3C2
0.050 GeneticVariation BEFREE To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N = 1639). 25686805

2015
dbSNP: rs5522
rs5522
NR3C2
0.050 GeneticVariation BEFREE There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits. 22584804

2013
dbSNP: rs5522
rs5522
NR3C2
0.050 GeneticVariation BEFREE Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD). 20884124

2011
dbSNP: rs5522
rs5522
NR3C2
0.050 GeneticVariation BEFREE In an elderly cohort, one of the functional MR gene variants, MR-I180V, associated with higher feelings of depression. 21164267

2011
dbSNP: rs5522
rs5522
NR3C2
0.050 GeneticVariation BEFREE Future studies are warranted to evaluate whether rs5522 genotype interacts with naturalistic stressors to increase the risk of depression and whether stress-induced anhedonia might moderate such risk. 20528958

2010