Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. 27073970

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of Val66Met polymorphism at brain derived neurotrophic factor gene with depression among Chinese adolescents after Wenchuan earthquake: An 18months longitudinal study. 28527683

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression. 25745134

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception. 26756166

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Additionally, the association between DED and Val66Met may vary by depression status. 26393465

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. 26976307

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression. 26000753

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression. 25648279

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models. 26795846

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. 22931410

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. 24433458

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood. 23880378

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. 23481907

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke. 23399480

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. 22883353

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE A brain-derived neurotrophic factor (BDNF) prodomain single-nucleotide polymorphism resulting in a valine to methionine substitution (Val66Met) has been associated with depression-related phenotypes and brain alterations involving regions consistently associated with major depressive disorder (MDD). 23165919

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression. 22033217

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD). 21692988

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction). 21880305

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis. 22610920

2012

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord. 20921572

2011