rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa.
|
27990443 |
2016 |
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Although the NOS3 G894T variant was not independently associated with diabetes in either African Americans or whites, significant interaction between BMI and the NOS3 polymorphism indicated that obesity was an effect modifier of diabetes risk for white individuals with the TT genotype (odds ratio (OR) for interaction = 1.65, p = 0.04).
|
24278136 |
2013 |
rs1799983
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|
|
0.090 |
GeneticVariation |
BEFREE |
In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes.
|
24603156 |
2013 |
rs1799983
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|
|
0.090 |
GeneticVariation |
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
rs1799983
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|
|
0.090 |
GeneticVariation |
BEFREE |
To determine the frequency of eNOS G894T variant and to find the possible association between this polymorphism with CAD we studied 207 unrelated patients with total CAD (with and without diabetes) and 92 controls.
|
21602253 |
2012 |
rs1799983
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|
|
0.090 |
GeneticVariation |
BEFREE |
The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively.
|
19773668 |
2009 |
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy.
|
18622262 |
2008 |
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The frequency of CC (-786T > C), TT (894G > T) and aa genotypes (27VNTR) were significantly higher in diabetic nephropathy patients as compared to the diabetes without nephropathy group (CC: P = 0.003, TT: P = 0.03, aa: P < 0.0001).
|
18401556 |
2008 |
rs1799983
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Age at onset of diabetes, male sex, duration of diabetes, HbA1c, blood pressure and smoking were assessed as possible confounders in the logistic regression analysis, which showed that homozygosity for the Glu-allele of the Glu298Asp-polymorphism was independently associated with increased risk of DN (OR = 1.46; 95% CI = 1.12-1.91).
|
17101543 |
2006 |