Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506). 28585683

2018

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study. 22265018

2013

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30). 23761423

2013

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238). 22466342

2012

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study. 20400278

2012

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE These results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, P = 1.3 x 10(-3); rs9939609, P = 9.8 x 10(-4); for obesity, rs8050136, P = 2.2 x 10(-7); rs9939609, P = 9.0 x 10(-9)). 20057365

2011

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. 21179003

2011

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE The rs9939609 polymorphism in the FTO gene is related to abnormal glucose levels and with LAP, a surrogate marker of diabetes and cardiovascular risk in postmenopause. 21868005

2011

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE For white participants, the FTO rs9939609 A allele was associated with an increased risk of diabetes (odds ratio (OR) = 1.19, p<0.001) and obesity (OR = 1.22, p<0.001) under an additive genetic model that was similar for all of the SNPs analyzed. 20502638

2010

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE We examined whether the FTO gene variant (rs9939609, T/A) is associated with body weight and BMI and long-term weight changes in the Finnish Diabetes Prevention Study (DPS). 19180072

2009

dbSNP: rs780094
rs780094
0.740 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE In the Danish MONICA study four gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154), C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0.0089), GCKR rs780094 (1.094, 1.007-1.188 , P = 0.0335) and C2CD4B rs11071657 (1.092, 1.007-1.183 , P = 0.0323). 23185617

2013

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE This study provides the first evidence that GCKR rs780094, a single-nucleotide polymorphism related to diabetes, may be associated with pancreatic cancer risk. 22015968

2012

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE The intronic single-nucleotide polymorphism (SNP) rs780094 (intron 16) and the missense SNP rs1260326 (P446L) in the GCKR gene are strongly associated with increased circulating triglyceride and C-reactive protein levels and, paradoxically, reductions in diabetes incidence, fasting glucose levels, and insulin resistance. 21525158

2011

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. 20661421

2010

dbSNP: rs587783672
rs587783672
0.720 GeneticVariation BEFREE Only one mutation (p.Glu227Lys in KCNJ11) co-segregated with diabetes in the family (with a LOD-score of 3.68). 22701567

2012

dbSNP: rs587783672
rs587783672
0.720 CausalMutation CLINVAR ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007. 18414213

2008

dbSNP: rs587783672
rs587783672
0.720 GeneticVariation BEFREE At follow-up of the TNDM patients with genetic alterations, 43% developed diabetes or impaired glucose tolerance in later life (one with 6q24 duplication and two with N48D and E227K mutations at KCNJ11 gene). 17490422

2007

dbSNP: rs1333049
rs1333049
0.710 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs4420638
rs4420638
0.710 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs4506565
rs4506565
0.710 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs4506565
rs4506565
0.710 GeneticVariation BEFREE The TCF7L2 SNP rs4506565, previously associated with diabetes, showed a similar, significant pharmacogenetic association. 24128935

2014

dbSNP: rs193929355
rs193929355
0.710 GeneticVariation BEFREE Nineteen children carrying KCNJ11 mutations associated with isolated diabetes (R201H; n = 8), diabetes with neurodevelopmental impairment (V59M or V59A [V59M/A]; n = 8), or diabetes not consistently associated with neurodevelopmental disability (Y330C, E322K, or R201C; n = 3) were studied using the age-standardized Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI). 22855734

2013

dbSNP: rs4420638
rs4420638
0.710 GeneticVariation BEFREE Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027). 23555584

2013