rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A nonsynonymous SNP +1858C/T (rs2476601) in the protein tyrosine phosphatase, nonreceptor type 22(PTPN22) gene leading to Arg 620 Trp substitution is known to be associated with susceptibility to type 1 diabetes (T1D) and several other autoimmune diseases.
|
24913133 |
2014 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that C1858T polymorphism in PTPN22 is associated with elevated T1D risk among Caucasian population.
|
23291413 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus.
|
23359562 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We highlight the pathogenic significance of the C1858T PTPN22 polymorphism in human autoimmunity with special reference to Type 1 diabetes.
|
23261816 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We investigated whether the PTPN22 C1858T polymorphism is associated with the autoimmune conditions present in the family of a child affected by type 1 diabetes (T1D) carrying the TT genotype (index patient) and the potential immunological effect of the variant.
|
22809281 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The aim of this study was the investigation for the first time of the association of PTPN22 C1858T polymorphism with T1DM in Greek population.
|
23936838 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Across all populations, significant associations were found between the PTPN22 C1858T polymorphism and susceptibility to T1D under genotypic (TT vs. CC [OR = 3.656, 95% CI: 3.139-4.257], CT vs. CC [OR = 1.968, 95% CI: 1.683-2.300]), recessive (OR = 3.147, 95% CI: 2.704-3.663), and dominant models (OR = 1.957, 95% CI: 1.817-2.108).
|
23438410 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.
|
23054006 |
2013 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
After stratification by ethnicity, analysis revealed that the PTPN22 C1858T</span> polymorphism T allele was significantly associated with T1D in Europeans, Americans (OR = 1.946, 95% CI = 1.852~2.045, P < 0.001; OR = 1.946, 95% CI = 1.690~2.242, P < 0.001, respectively).
|
22429252 |
2012 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We set out to analyze the role of two major non-HLA gene polymorphisms associated with type 1 diabetes (T1D), PTPN22 1858C/T and insulin gene INS-23 A/T in progression to clinical T1D after the appearance of β-cell autoimmunity.
|
22357962 |
2012 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The results showed a remarkable pattern; PTPN22 C1858T was strongly associated with type I diabetes, rheumatoid arthritis, immune thrombocytopenia, generalized vitiligo with concomitant autoimmune diseases, idiopathic inflammatory myopathies, Graves' disease, juvenile idiopathic arthritis, myasthenia gravis, systemic lupus erythematosus, anti-neutrophil cytoplasmic antibody-associated vasculitis and Addison's disease.
|
23076337 |
2012 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The T allele of the C1858T variant is positively associated with proinsulin levels during the first 12 months in newly diagnosed type 1 diabetes children.
|
21429197 |
2011 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We found a significant association between PTPN22 1858 C/T SNP and T1D and GD.
|
21467606 |
2011 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
These results indicate that the PTPN22 gene polymorphism independent of the SNP rs2476601 might be a supplementary risk factor to AITD, but not in T1D in Koreans, contradicting a major contributory influence of the PTPN22 gene in explaining common mechanism underlying multiple autoimmune diseases.
|
22069277 |
2011 |
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
G(-1123)C and C1858T were in linkage disequilibrium (D' = 0.98; r(2) =0.61 in T1DM and D' = 0.97; r(2) =0.41 in controls).
|
20518841 |
2010 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
To evaluate the prevalence of PTPN22 C1858T polymorphism in young type 1 diabetes patients with or without autoimmune thyroiditis.
|
20438787 |
2010 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
This significant haplotype distribution difference suggests that polymorphisms in the PTPN22 gene other than R620W are involved in either predisposition to or protection from T1D in the Japanese population.
|
20510318 |
2010 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis.
|
20445565 |
2010 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D).
|
19090780 |
2009 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Fourth, at PTPN22, there was evidence for a novel contribution to T1D risk, independent of the replicated effect of the R620W variant.
|
19956109 |
2009 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.
|
19473815 |
2009 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |