rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA).
|
30456822 |
2019 |
rs689
|
|
|
0.790 |
GeneticVariation |
GWASCAT |
Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study.
|
31152121 |
2019 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The adenine at rs689 is strongly associated with type 1 diabetes.
|
31150930 |
2019 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
In this work we show that the analysis of non-HLA related to type 1 diabetes in the INS-VNTR, SNP rs689, and rs3842753 improves the identification of these patients.
|
26273670 |
2015 |
rs689
|
|
T |
0.790 |
GeneticVariation |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A gene-gene interaction in the T1D data were observed between the IL2RA rs2104286 and GIMAP4 rs9640279 (OR 1.52, p = 0.0064) and indicated between INS rs689 and GIMAP5 rs2286899.
|
25964488 |
2015 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
INS gene polymorphism rs689 and IKZF4 polymorphism (rs1701704) were strongly associated with IAA positivity at the time of T1D diagnosis (p = 0.000004 and 0.00044, respectively).
|
23721563 |
2013 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The methylation of CpG -69, -102, -180, -206, but not CpG -19, -135, -234 was strongly influenced by the cis-genotype at rs689, a SNP known to show a strong association with T1D.
|
22567146 |
2012 |
rs689
|
|
A |
0.790 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
rs689
|
|
|
0.790 |
GeneticVariation |
BEFREE |
In addition, rs689 was associated with age-at-diagnosis of T1D (P=0.001), with homozygosity for the T1D protective T allele, delaying the onset of T1D by approximately 2 years in these families.
|
19956106 |
2009 |