|
rs104893642
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.
|
12679424 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM.
|
9589236 |
1998 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15127203 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly972Arg is more common than other known mutations in our population but may not be a major determinant in genetic susceptibility to type 2 diabetes.
|
16284438 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg, is more common in Mexican Americans and Caucasians, but is not a major contributor to genetic susceptibility to Type 2 diabetes.
|
11025561 |
2000 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
|
22994406 |
2012 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in the IRS genes have been identified, but only the Gly-->Arg972 substitution of IRS-1, interacting with environmental factors, seems to have a pathogenic role in the development of type 2 diabetes.
|
11641236 |
2001 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants.
|
19557384 |
2009 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most commonly detected polymorphism in human insulin receptor substrate-1 (IRS-1), a glycine to arginine change at codon 972 (G972R), is associated with an increased risk of Type 2 diabetes and insulin resistance.
|
15590636 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1.
|
11978638 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied possible relations between GDM and both insulin receptor substrate 1 (IRS-1) (Gly972Arg) and beta3-adrenergic receptor (ADRB3 Trp64Arg, beta3-AR) gene mutations, considered potential modifying factors in the etiology of type 2 diabetes mellitus.
|
17046546 |
2006 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad.
|
24612564 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg of IRS-1 gene does not play an important role in the development of NIDDM in this population.
|
8732707 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian.
|
26582067 |
2016 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03).
|
12819898 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly972Arg mutation in the IRS-1 gene has been found to be associated with insulin resistance and type II diabetes.
|
12588284 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms in a large and ethnically homogeneous sample that IRS1 G972R polymorphism is associated with failure to OAD among patients with T2D.
|
24947357 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
|
19716569 |
2010 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SSCP variants that change the sequence of the protein, delta S686/687 (deletion of the codons for serine-686 and 687) and G972R, were identified in two different NIDDM subjects, both whom were also heterozygous for the V101I polymorphisms in GLUT2.
|
7713316 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the IRS-1 Gly972Arg variant does not substantially increase risk of common Type 2 diabetes, or Type 2 diabetes in obese persons.
|
15209769 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D.
|
28696414 |
2018 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS.
|
16603055 |
2006 |