|
rs10498210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRS1- rs10498210 G/A and CCR5-59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan.
|
30884193 |
2019 |
|
rs13431554
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs13431554 in the IRS-1 gene was associated with a hyperreactive platelet phenotype in the CAD patients with T2DM.
|
27005817 |
2016 |
|
rs1801118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the prevalence of each of these polymorphisms was not statistically different between NIDDM and control subjects, the prevalence of the four IRS-1 polymorphisms with an amino acid substitution together was significantly higher in NIDDM than in control subjects (23.4 vs 8.5%, p < 0.05), and two substitutions (Met 209 --> Thr and Ser809 --> Phe) were found only in NIDDM patients.
|
8739921 |
1996 |
|
rs1801120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the prevalence of each of these polymorphisms was not statistically different between NIDDM and control subjects, the prevalence of the four IRS-1 polymorphisms with an amino acid substitution together was significantly higher in NIDDM than in control subjects (23.4 vs 8.5%, p < 0.05), and two substitutions (Met 209 --> Thr and Ser809 --> Phe) were found only in NIDDM patients.
|
8739921 |
1996 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS.
|
16603055 |
2006 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We studied a simple tandem repeat DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-->Pro) and 972 (Gly-->Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan.
|
8037748 |
1994 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed a significant difference in the genotype distribution and allele frequency between the T2DM cases and controls for single nucleotide polymorphism (SNP) rs1801278 (OR 17.61, 95% CI 8.06-38.4, p < 0.001).
|
31446532 |
2019 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D.
|
28696414 |
2018 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian.
|
26582067 |
2016 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We failed to find any association between the IRS1 Gly972Arg polymorphism and T2DM.
|
26620983 |
2015 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad.
|
24612564 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms in a large and ethnically homogeneous sample that IRS1 G972R polymorphism is associated with failure to OAD among patients with T2D.
|
24947357 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PPARG Pro12 is associated with insulin resistance and this polymorphism interacts with IRS1 Gly972Arg, to increase the risk of T2DM in the mixed-ancestry population of South Africa.
|
24447396 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population.
|
24493031 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.
|
24071662 |
2013 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
|
22994406 |
2012 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Heterozygosity for the Gly972Arg variant of the IRS1 gene showed the strongest association for T2D in both analyzed samples (OR = 2.43, 95% CI 1.12-5.26 and 2.64, 95% CI 1.37-5.10, respectively).
|
21834909 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
|
19716569 |
2010 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants.
|
19557384 |
2009 |