|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg, is more common in Mexican Americans and Caucasians, but is not a major contributor to genetic susceptibility to Type 2 diabetes.
|
11025561 |
2000 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly972Arg is more common than other known mutations in our population but may not be a major determinant in genetic susceptibility to type 2 diabetes.
|
16284438 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg of IRS-1 gene does not play an important role in the development of NIDDM in this population.
|
8732707 |
1996 |
|
rs104893642
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.
|
12679424 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03).
|
12819898 |
2003 |
|
rs1801118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the prevalence of each of these polymorphisms was not statistically different between NIDDM and control subjects, the prevalence of the four IRS-1 polymorphisms with an amino acid substitution together was significantly higher in NIDDM than in control subjects (23.4 vs 8.5%, p < 0.05), and two substitutions (Met 209 --> Thr and Ser809 --> Phe) were found only in NIDDM patients.
|
8739921 |
1996 |
|
rs1801120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the prevalence of each of these polymorphisms was not statistically different between NIDDM and control subjects, the prevalence of the four IRS-1 polymorphisms with an amino acid substitution together was significantly higher in NIDDM than in control subjects (23.4 vs 8.5%, p < 0.05), and two substitutions (Met 209 --> Thr and Ser809 --> Phe) were found only in NIDDM patients.
|
8739921 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.
|
10482045 |
1999 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 130 patients with type-2 diabetes mellitus (DM), we identified 6 who were heterozygous for the Gly972Arg mutation.
|
10844412 |
1999 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
|
19716569 |
2010 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Despite genotyping 9,000 people and >95% power to reproduce the estimated OR from the recent meta-analysis, we were unable to replicate the association of the IRS-1 G972R polymorphism with type 2 diabetes.
|
15561965 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabetes, we and others have not observed this association in well-powered samples.
|
17443311 |
2007 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
From statistical analysis carried out here, individually, the Pst I, Nsi I and Gly972Arg polymorphisms were not associated with the type 2 diabetes, obese or hypertensive phenotypes in this population.
|
15581831 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Heterozygosity for the Gly972Arg variant of the IRS1 gene showed the strongest association for T2D in both analyzed samples (OR = 2.43, 95% CI 1.12-5.26 and 2.64, 95% CI 1.37-5.10, respectively).
|
21834909 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D.
|
28696414 |
2018 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population.
|
24493031 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance.
|
19924153 |
2009 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS.
|
16603055 |
2006 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS.
|
16603055 |
2006 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants.
|
19557384 |
2009 |
|
rs10498210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRS1- rs10498210 G/A and CCR5-59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan.
|
30884193 |
2019 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene.
|
16877540 |
2006 |