Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799884
rs1799884
GCK
0.830 GeneticVariation BEFREE Overall, the pooled results indicated that GCK (rs1799884), GCKR (rs780094) and MTNR1B (rs10830963) were significantly associated with T2DM susceptibility (OR, 1.04; 95%CI, 1.01-1.08; OR, 1.08; 95%CI, 1.05-1.12 and OR, 1.05; 95%CI, 1.02-1.08, respectively). 23840762

2014

dbSNP: rs1799884
rs1799884
GCK
0.830 GeneticVariation BEFREE The GCK rs1799884 A allele was significantly associated with decreased HOMA-B (p([add]) = 0.0005), but not with type 2 diabetes or IFG. 19241058

2009

dbSNP: rs1799884
rs1799884
GCK
0.830 GeneticVariation BEFREE The SNP rs1799884 in the GCK promoter was associated with elevated fasting plasma glucose (fPG) concentrations that remained unchanged during the follow-up period (P = 0.4; SE 0.004 [-0.003-0.007]) but did not predict future type 2 diabetes (HR 0.9 [0.8-1.0], P = 0.1). 18332101

2008

dbSNP: rs587780346
rs587780346
0.010 GeneticVariation BEFREE The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent. 21978167

2013

dbSNP: rs104894008
rs104894008
0.010 GeneticVariation BEFREE Here we report the isolation and partial sequence of the human glucokinase gene and the identification of two missense mutations in exon 7, Thr-228----Met and Gly-261----Arg, that cosegregate with early-onset non-insulin-dependent diabetes mellitus. 1502186

1992