Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893642
rs104893642
0.710 GeneticVariation BEFREE A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. 12679424

2003

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis. 26582067

2016

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad. 24612564

2015

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population. 24493031

2015

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE IRS1 G972R missense polymorphism is associated with failure to oral antidiabetes drugs in white patients with type 2 diabetes from Italy. 24947357

2014

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry. 24071662

2014

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance. 19924153

2010

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants. 19557384

2010

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study. 19716569

2009

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabetes, we and others have not observed this association in well-powered samples. 17443311

2007

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. 17570749

2007

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene. 16877540

2006

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE We studied possible relations between GDM and both insulin receptor substrate 1 (IRS-1) (Gly972Arg) and beta3-adrenergic receptor (ADRB3 Trp64Arg, beta3-AR) gene mutations, considered potential modifying factors in the etiology of type 2 diabetes mellitus. 17046546

2006

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes. 15561965

2005

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The most commonly detected polymorphism in human insulin receptor substrate-1 (IRS-1), a glycine to arginine change at codon 972 (G972R), is associated with an increased risk of Type 2 diabetes and insulin resistance. 15590636

2005

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2). 14988278

2004

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies. 12819898

2004

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies. 15209769

2004

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The Gly972Arg mutation in the IRS-1 gene has been found to be associated with insulin resistance and type II diabetes. 12588284

2003

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1. 11978638

2002

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes. 12213887

2002

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Several polymorphisms in the IRS genes have been identified, but only the Gly-->Arg972 substitution of IRS-1, interacting with environmental factors, seems to have a pathogenic role in the development of type 2 diabetes. 11641236

2001

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Gly971Arg, is more common in Mexican Americans and Caucasians, but is not a major contributor to genetic susceptibility to Type 2 diabetes. 11025561

2000

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM. 9589236

1998

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial. 9162610

1997