Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893642
rs104893642
0.710 GeneticVariation BEFREE A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. 12679424

2003

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The results showed a significant difference in the genotype distribution and allele frequency between the T2DM cases and controls for single nucleotide polymorphism (SNP) rs1801278 (OR 17.61, 95% CI 8.06-38.4, p < 0.001). 31446532

2019

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D. 28696414

2018

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian. 26582067

2016

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE We failed to find any association between the IRS1 Gly972Arg polymorphism and T2DM. 26620983

2015

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE We replicated the significant association of rs1801278 and rs3792267 SNPs of the IRS1 and CAPN10 genes with T2DM in the population of Hyderabad. 24612564

2014

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE This study confirms in a large and ethnically homogeneous sample that IRS1 G972R polymorphism is associated with failure to OAD among patients with T2D. 24947357

2014

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The PPARG Pro12 is associated with insulin resistance and this polymorphism interacts with IRS1 Gly972Arg, to increase the risk of T2DM in the mixed-ancestry population of South Africa. 24447396

2014

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population. 24493031

2014

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry. 24071662

2013

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group. 22994406

2012

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women. 20540670

2011

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population. 21612394

2011

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Heterozygosity for the Gly972Arg variant of the IRS1 gene showed the strongest association for T2D in both analyzed samples (OR = 2.43, 95% CI 1.12-5.26 and 2.64, 95% CI 1.37-5.10, respectively). 21834909

2011

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study. 19716569

2010

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants. 19557384

2009

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance. 19924153

2009

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabetes, we and others have not observed this association in well-powered samples. 17443311

2007

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE We studied possible relations between GDM and both insulin receptor substrate 1 (IRS-1) (Gly972Arg) and beta3-adrenergic receptor (ADRB3 Trp64Arg, beta3-AR) gene mutations, considered potential modifying factors in the etiology of type 2 diabetes mellitus. 17046546

2006

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS. 16603055

2006

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene. 16877540

2006

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE Gly972Arg is more common than other known mutations in our population but may not be a major determinant in genetic susceptibility to type 2 diabetes. 16284438

2005

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE The most commonly detected polymorphism in human insulin receptor substrate-1 (IRS-1), a glycine to arginine change at codon 972 (G972R), is associated with an increased risk of Type 2 diabetes and insulin resistance. 15590636

2005

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland. 17570749

2005

dbSNP: rs1801278
rs1801278
0.100 GeneticVariation BEFREE From statistical analysis carried out here, individually, the Pst I, Nsi I and Gly972Arg polymorphisms were not associated with the type 2 diabetes, obese or hypertensive phenotypes in this population. 15581831

2005