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rs1052133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear.
|
24998955 |
2014 |
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rs1052133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
According to our study results, it has been observed that the combined evaluation of GSTM1-GSTT1-GSTP1 and OGG1 Ser326Cys gene polymorphisms can be used as candidate genes in the etiology of T2DM, especially in the development of T2DM.
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22652274 |
2012 |
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rs1052133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, a significantly increased risk of T2DM was observed in the subjects carrying heterozygous variant of c.-23A>G and homozygous mutation of Ser326Cys (OR=3.684, 95%CI=1.400-9.697).
|
20562008 |
2010 |
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rs1052133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Of the SNPs examined for association, the Ser(326)Cys (rs1052133) exhibited significant association with T2DM (</span>p = 0.016) after accounting for age and sex effects.
|
20606456 |
2010 |
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rs1052133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The association of the Ser326Cys polymorphism of the 8-oxoguanine glycosylase 1 (OGG1) gene with type 2 diabetes was examined using a Japanese population (n (M/W): 4585 (2085/2500); age: 62.6 +/- 10.9 years).
|
19486888 |
2009 |
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rs1801126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we screened for the polymorphism variants Val83Met (c.247G>A, rs4866) in hMTH1; c.-53G>C (rs56387615), c.-23A>G (rs1801129) and c.-18G>T (rs1801126) in the 5'-UTR of hOGG1; and AluYb8 insertion in MUTYH (AluYb8MUTYH, rs10527342) and investigated their synergistic effect on the risk of T2DM in the Chinese population.
|
23396182 |
2013 |
|
rs1801129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we screened for the polymorphism variants Val83Met (c.247G>A, rs4866) in hMTH1; c.-53G>C (rs56387615), c.-23A>G (rs1801129) and c.-18G>T (rs1801126) in the 5'-UTR of hOGG1; and AluYb8 insertion in MUTYH (AluYb8MUTYH, rs10527342) and investigated their synergistic effect on the risk of T2DM in the Chinese population.
|
23396182 |
2013 |
|
rs56387615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we screened for the polymorphism variants Val83Met (c.247G>A, rs4866) in hMTH1; c.-53G>C (rs56387615), c.-23A>G (rs1801129) and c.-18G>T (rs1801126) in the 5'-UTR of hOGG1; and AluYb8 insertion in MUTYH (AluYb8MUTYH, rs10527342) and investigated their synergistic effect on the risk of T2DM in the Chinese population.
|
23396182 |
2013 |
|
rs2072668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another intronic variant (rs2072668), which was in strong linkage disequilibrium (r(2) = 0.96) with Ser(326)Cys also exhibited significant association with T2DM (p = 0.031).
|
20606456 |
2010 |