|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, the rs10946398 CC/CA genotypes, as well as the C allele increased the risk of T2D.
|
30185902 |
2018 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, no significant association was detected between HHEX (rs1111875), CDKAL1 (rs7756992), or UBE2E2 (rs7612463) and T2D.
|
29871606 |
2018 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.
|
28821857 |
2017 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
HbA1c reduction after use of DPP-4 inhibitors for 3 months was significantly greater in patients with a risk allele for type 2 diabetes (GG -0.4%, CG -0.5%, CC -0.8%, p = 0.02 for rs7754840 and AA -0.4%, AG -0.5%, GG -0.8%, p = 0.01 for rs7756992).
|
27139004 |
2016 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
HbA1c reduction after use of DPP-4 inhibitors for 3 months was significantly greater in patients with a risk allele for type 2 diabetes (GG -0.4%, CG -0.5%, CC -0.8%, p = 0.02 for rs7754840 and AA -0.4%, AG -0.5%, GG -0.8%, p = 0.01 for rs7756992).
|
27139004 |
2016 |
|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Cyclin- dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 (CDKAL1) rs10946398, a novel body mass index (BMI)-associated locus specifically in the Asian population, may impair insulin secretion and may be associated with insulin resistance and type 2 diabetes.
|
26119585 |
2015 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNP rs7754840</span> in CDKAL1, rs864745 in JAZF1, and rs35767 in IGF1 might serve as potential susceptibility loci for T2DM in Uyghurs.
|
25785549 |
2015 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians.
|
25755232 |
2015 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of the rs7756992 of CDKAL1 and the rs4402960 of IGF2BP2 with Type 2 diabetes, diabetic complications (nephropathy, retinopathy and cardiovascular disease), obesity and hypertension in a Tunisian population.
|
24636221 |
2015 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a simple linear regression model, expression of CDKAL1-v1 was associated with the lead type 2 diabetes-associated SNP, rs7756992, in whole blood and islets.
|
25634229 |
2015 |
|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples.
|
24736664 |
2014 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, simulation analysis indicated that a type 2 diabetes risk variant in CDKAL1 (rs7754840) was selected in East Asians ∼6,900 years ago.
|
25222615 |
2014 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations.
|
24898818 |
2014 |
|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Taken together, our findings provide evidence for a significant contribution of CDKN2A/B gene rs10811661 and CDKAL1 gene rs7756992 and rs10946398 to type 2 diabetes.
|
24012816 |
2013 |
|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05).
|
23298195 |
2013 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs.
|
23458876 |
2013 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In meta-regression analyses, age was found to exert a significant influence on the association between rs10811661 and type 2 diabetes (P=0.003), as well as between rs7754840 and gender (P=0.034).
|
24012816 |
2013 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the whole population, a significant association was found between CDKAL1 gene rs7756992 A/G polymorphism and T2DM under allelic (OR: 1.180, 95% CI: 1.130-1.230, P = 1.60 × 10⁻¹⁴), recessive (OR: 1.510, 95% CI: 1.380-1.660, P = 8.41 × 10⁻¹⁸), dominant (OR: 1.175, 95% CI: 1.109-1.246, P = 6.30 × 10⁻⁸), homozygous (OR: 1.400, 95% CI: 1.282-1.530, P = 8.02 × 10⁻¹⁴), and heterozygous genetic models (OR: 1.101, 95% CI: 1.040-1.166, P = 0.001).
|
24185407 |
2013 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Taken together, our findings provide evidence for a significant contribution of CDKN2A/B gene rs10811661 and CDKAL1 gene rs7756992 and rs10946398 to type 2 diabetes.
|
24012816 |
2013 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After correcting for multiple testing, however, only the association between T2D and rs7754840 at CDKAL1 (P < 1×10(-4)) remains significant.
|
21643948 |
2012 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7903146 (TCF7L2), association was observed for early-onset type 2 diabetes.
|
22923468 |
2012 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two loci known to be associated with type 2 diabetes had a genome-wide significant association with GDM in the joint analysis. rs7754840, a variant in CDKAL1, had the strongest association with GDM (odds ratio 1.518; P=6.65×10(-16)).
|
22233651 |
2012 |
|
rs7756992
|
|
|
0.900 |
GeneticVariation |
BEFREE |
All the five SNPs were significantly associated with T2D risk with overall effects (odds ratio, OR) from 1.19 to 1.29 in the additive genetic model (rs6931514: OR=1.29, 95% confidence intervals (95% CI)=1.19-1.39, P=5.6 × 10(-10); rs7756992: OR=1.23, 95% CI=1.15-1.32, P=1.2 × 10(-8); rs4712523: OR=1.25, 95% CI=1.15-1.35, P=3.8 × 10(-8); rs4712524: OR=1.24, 95% CI=1.15-1.35, P=6.8 × 10(-8); rs9472138: OR=1.19, 95% CI=1.05-1.34, P=006).
|
22437209 |
2012 |