Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE NOS3 894G>T polymorphism is associated with progression of kidney disease and cardiovascular morbidity in type 2 diabetic patients: NOS3 as a modifier gene for diabetic nephropathy? 24603156

2014

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN. 23260854

2013

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE We performed a meta-analysis of 28 association studies focusing on three polymorphisms in the NOS3 gene (G894T (Glu289Asp), 4b/a, and T-786C) and the risk of DN published before July 2009, covering a total of 10,364 subjects. 20049477

2011

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively. 19773668

2009

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy. 18622262

2008

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene variants with diabetic nephropathy. 18413207

2008

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE These results suggest that the eNOS gene locus is associated with diabetic nephropathy and the functional polymorphisms (-786T > C & 894G > T) might lead to a decreased expression of eNOS gene. 18401556

2008

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy. 17101543

2007

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy. 15331206

2005