|
rs8111874
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The meta-analysis (N = 5758) followed by replication (N = 3784) identified a genome-wide significant association between rs8111874 and diarrhoea at age 1 year.
|
27559109 |
2016 |
|
rs8111874
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
The meta-analysis (N = 5758) followed by replication (N = 3784) identified a genome-wide significant association between rs8111874 and diarrhoea at age 1 year.
|
27559109 |
2016 |
|
rs12462111
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.
|
27559109 |
2016 |
|
rs35106244
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.
|
27559109 |
2016 |
|
rs1131692245
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1163944538
|
|
GA |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1352010373
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs138504221
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs142110773
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs150726175
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555206402
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1555909961
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs370244148
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs529855742
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs752914124
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Associations were found between toxicities and gene variants (P<0.05), including neutropenia with ABCB1 (rs1045642) and SLC0B3 (rs4149117 and rs7311358); and diarrhoea with CYP2C9 (rs1057910), CYP2C19 (rs3758581), UGT1A6 (rs4124874) and SLC22A1 (rs72552763).
|
28817838 |
2017 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No significant differences were found in the AUC0-24 or C0 for gefitinib or in the frequency of diarrhea, skin rash or hepatotoxicity among the CYP3A4, CYP3A5, CYP2D6, ABCG2 (421C>A), and ABCB1 (1236C>T, 2677G>T/A, and 3435C>T) genotype groups.
|
25554506 |
2015 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asthenia(OR = 0.047; 95 % CI = 0.004–0.493; P = 0.011) and Tallele of ABCB1 C3435T SNP was associated with a lower risk of diarrhea (OR = 0.177; 95 % CI = 0.034–0.919;P = 0.039), and individuals with two copies of GSTT1 gene had a lower risk for asthenia (OR = 0.093; 95 %CI = 0.011–0.794; P = 0.030).
|
23543295 |
2013 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Statistical associations were observed, suggesting a lower risk of neutropenia (p = 0.013) and hand-foot syndrome (HFS; p = 0.027) for the carriers of T variation for rs1128503 in capecitabine-treated patients, carriers of T variation for rs1045642 treated with capecitabine had a lower risk of HFS (p = 0.033), while those treated with 5-FU had a higher risk of diarrhea (p = 0.035), and carriers of T variation for rs2032592 treated with capecitabine were at less risk of developing HFS (p = 0.033).
|
21142915 |
2010 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia.
|
19349543 |
2009 |
|
rs2231142
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Particularly, the afatinib plasma concentration was higher and diarrhea was more severe in patients carrying the A allele of ABCG2 C421A.
|
31319966 |
2019 |
|
rs4149056
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Of these, 19 sets gave relatively good description of the effect of UGT1A1 *28 and SLCO1B1 c.521T>C polymorphism on the SN-38 plasma concentration, neutropenia, and diarrhea observed in clinical studies reported mainly by Teft et al.(Br J Cancer.112(5):857-65, 20).
|
28397089 |
2017 |
|
rs4149056
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meta-analysis showed east-Asian patients expressing SLCO1B1 521T>C or 1118G>A to have a two- to fourfold increased risk of irinotecan-induced neutropenia but not diarrhea.
|
27380948 |
2016 |
|
rs4149056
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Polymorphisms in SLCO1B1 (rs2306283, rs4149056) were associated with diarrhea and thrombocytopenia, respectively.
|
27533851 |
2016 |
|
rs2231142
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study demonstrates that the ABCG2 Q141K </span>polymorphism may correlate with chemotherapy-induced di</span>arrhea in patients with DLBCL who have received frontline R-CHOP chemotherapy, and this has implications for optimizing treatment with such agents.
|
19032367 |
2008 |