|
rs10030601
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
|
22949513 |
2012 |
|
rs10030601
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
|
22949513 |
2012 |
|
rs10157763
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with the risk genotype (rs10157763, AA) presented with low scores on the Glasgow Coma Scale and high rate of epileptic seizures.
|
27193124 |
2016 |
|
rs10234411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs776746 and rs15524 in the CYP3A5 gene tend to affect CBZ metabolism, and rs2032582, rs10234411 in the ABCB1 gene may contribute to inter-individual variation in CBZ and in CBZ-E transport among patients with epilepsy using CBZ in combination with PHT or PB.
|
26421491 |
2015 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of a tag SNP of the CCL2 gene, rs1024611 (originally designated as -2578G>A or -2518G>A) with drug-resistant epilepsy in Chinese children with epilepsy.
|
23996681 |
2013 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene.
|
18436433 |
2008 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the ABCB1 C3435T polymorphism may be a genetic marker for drug resistance in epilepsy in Caucasian populations.
|
25799371 |
2015 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transporters are also thought to be involved in the transport of antiepileptic drugs.
|
19167193 |
2009 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ABCB1 T-129C, C1236T, G2677T/A and C3435T polymorphisms were genotyped in 210 Japanese epileptics who had been prescribed AEDs, including CBZ, for longer than 2 years.
|
16753003 |
2006 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Whether the C3435T polymorphism can act as a marker for the natural history of treated epilepsy remains to be determined.
|
15857428 |
2005 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One hundred and eight patients with drug-responsive epilepsy, 63 patients with drug-resistant epilepsy, and 219 control migraine subjects were studied, but the analysis for C3435T allele showed no significant association between the CC genotype and the multidrug-resistant epilepsy.
|
16542858 |
2006 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that C3435T is unlikely to be a marker for epilepsy multidrug resistance.
|
17460550 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy.
|
24213830 |
2014 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We suggest that the influence of the C3435T polymorphism in predicting the drug-resistance in epilepsy, might be significant and further investigations focusing on carbamazepine and phenytoin, in various ethnic populations are necessary to clarify the effect of C3435T polymorphism on the multidrug resistance in epilepsy patients.
|
24300029 |
2014 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For a single gene test, it was demonstrated that 3435C>T in the ABCB1 gene had a significant effect on epilepsy treatment responses, but polymorphisms in the NR1I2 gene did not.
|
17924830 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G2677T T and C3435T T alleles as well as the TT, CTT and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in our population.
|
29198163 |
2018 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified.
|
24553780 |
2014 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested that ABCB1 rs1045642 and UGT2B7 rs7439366 may affect OXC pharmacokinetics and therapeutic efficacy in Han Chinese patients with epilepsy.
|
28837897 |
2017 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.
|
21388909 |
2011 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy.
|
25458099 |
2015 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34).
|
20491876 |
2010 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We failed to show an association between the ABCB1 C3435T polymorphism and the risk of drug-resistance suggesting a revision in contribution of this polymorphism in the multi-drug transporters hypothesis of pharmacoresistance to AEDs in epilepsy.
|
20605481 |
2010 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ABCB1 3435C>T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls.
|
17521963 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, the authors investigated the association between the MDR1 gene polymorphisms, C3435T and G2677AT, and drug resistance epilepsy by using polymerase chain reaction/restriction fragment length polymorphism and pyrosequencing methods in a group of 39 patients with drug-resistant epilepsy and 92 controls.
|
20448249 |
2010 |