|
rs2736100
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers.
|
31721021 |
2020 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers.
|
31721021 |
2020 |
|
rs4977756
|
|
|
0.900 |
GeneticVariation |
BEFREE |
It was found that the AG and GG genotypes of the rs4977756 (CDKN2A/B) were associated with an increased risk of gliomas (OR 1.85 and OR 2.38) and glioblastomas (OR 2.77 and OR 3.94).
|
31721021 |
2020 |
|
rs498872
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, the genotype AA of the rs498872 (PHLDB1)</span> was associated with poor overall survival of gliomas</span> patients (AA vs. GA, p = 0.037).
|
31721021 |
2020 |
|
rs6010620
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs6010620 (RTEL1), rs4977756 (CDKN2A/B), and rs498872 (PHLDB1) are associated with glioma risk in the Portuguese population and these data may contribute to understanding gliomas etiology.
|
31721021 |
2020 |
|
rs2736100
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In particular, both homozygous GG (P = 1.91 × 10, OR1 = 2.01) and heterozygous GT (P = 7.75 × 10, OR2 = 1.35) genotypes of rs4295627 were associated with glioma risk.
|
31277128 |
2019 |
|
rs498872
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings suggested that the rs498</span>872 polymorphism may serve as a potential genetic biomarker of glioma in both Asians and Caucasians.
|
30684220 |
2019 |
|
rs498872
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
|
rs6010620
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
|
rs4977756
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of the present study clearly show that the G allele of the rs4295627 polymorphism significantly increases the risk of glioma.
|
29264887 |
2017 |
|
rs498872
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, this study found that PHLDB1 rs498872 polymorphism was significantly associated with glioma</span> risk in Chinese Han population.
|
28886307 |
2017 |
|
rs2736100
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
|
rs4977756
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
|
rs4977756
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, we found an association between rs1412829 and rs4977756 (9p21.3, CDKN2B-AS1) and global DNA methylation pattern in glioma, for which a trend was seen also in the TCGA glioblastoma dataset.
|
27780202 |
2016 |
|
rs4977756
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The CDKN2A/B rs4977756 polymorphism is obvious increase the risk of glioma in Caucasians.
|
26577493 |
2016 |
|
rs498872
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
|
rs6010620
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
|
rs4295627
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Thus, our meta-analysis suggests that the rs4295627 SNP is associated with an increased risk of glioma.
|
26505354 |
2015 |
|
rs498872
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that rs498872 polymorphism was associated with increased risk of glioma.
|
24935770 |
2015 |
|
rs498872
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found 1.17-1.34-fold increased risk of glioma associated with rs498872 genotypes (OR 1.34, 95% CI 1.22-1.46; OR 1.24, 95% CI 1.14-1.35; OR 1.20, 95% CI 1.10-1.31; OR 1.17, 95% CI 1.08-1.27).
|
25182002 |
2015 |
|
rs2736100
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Taken together, these data suggested that TERT rs2736100 polymorphism may contribute to glioma susceptibility.
|
24888789 |
2014 |
|
rs2736100
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |