Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1344172059
rs1344172059
T 0.700 GeneticVariation CLINVAR

dbSNP: rs141322087
rs141322087
T 0.700 GeneticVariation CLINVAR

dbSNP: rs1553265736
rs1553265736
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1559279177
rs1559279177
HJV
T 0.700 CausalMutation CLINVAR

dbSNP: rs587782927
rs587782927
DSP
C 0.700 GeneticVariation CLINVAR

dbSNP: rs748379243
rs748379243
A 0.700 CausalMutation CLINVAR

dbSNP: rs766265889
rs766265889
A 0.700 GeneticVariation CLINVAR

dbSNP: rs794728602
rs794728602
A 0.700 GeneticVariation CLINVAR

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE The DD allele frequency is lower in Chinese, but the M235T variant of the angiotensinogen gene is more common in Chinese than whites; it is not known to what extent polymorphisms of the renin-angiotensin system affect clinical status or prognosis in Chinese patients with heart failure. 10097225

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.010 GeneticVariation BEFREE The DD allele frequency is lower in Chinese, but the M235T variant of the angiotensinogen gene is more common in Chinese than whites; it is not known to what extent polymorphisms of the renin-angiotensin system affect clinical status or prognosis in Chinese patients with heart failure. 10097225

1999

dbSNP: rs121918090
rs121918090
TTR
0.010 GeneticVariation BEFREE We describe two Italian first cousins with familial amyloidotic polyneuropathy associated with transthyretin variant consisting of the substitution of alanine for glycine at codon 47 (TTR Ala-47), from a family with a history of cardiac failure. 10677864

2000

dbSNP: rs121918080
rs121918080
TTR
0.010 GeneticVariation BEFREE A 47-year-old man started developing severe diarrhea and weight loss at age 41 years, followed by urinary incontinence, autonomic-nervous-system abnormalities and serious heart failure; the diagnosis of FAP (ATTR Ser50Ile) was made on the basis of genetic, histochemical and immunohistochemical analysis. 10834537

2000

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE These data suggest that the beta(1)-receptor Ser49Gly variant might be associated with altered receptor function, resulting in myocardial protection in patients with heart failure. 11052857

2000

dbSNP: rs1800888
rs1800888
0.040 GeneticVariation BEFREE Of particular importance, the Thr164Ile polymorphism, which is found in approximately 4% of humans, shows decreased receptor signaling, blunted cardiac response when expressed in transgenic mice, and is associated with a decreased survival rate in patients with congestive heart failure. 11222464

2001

dbSNP: rs61195471
rs61195471
0.010 GeneticVariation BEFREE In family A a missense mutation (nucleotide G607A, amino acid E203K) was identified in 14 adult subjects; disease was manifest as progressive conduction disease in the fourth and fifth decades.Death was caused by heart failure. 11561226

2001

dbSNP: rs111033560
rs111033560
0.010 GeneticVariation BEFREE Strikingly, both individuals homozygous for L39stop developed dilated cardiomyopathy and heart failure, requiring cardiac transplantation at ages 16 and 27. 12639993

2003

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure. 12767551

2003

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. 12921807

2003

dbSNP: rs1320702652
rs1320702652
0.040 GeneticVariation BEFREE Possession of the C34T (Glu12Stop) nonsense mutation in the AMP-deaminase 1 (AMPD1) gene has been shown to be associated with improved prognosis in heart failure and ischemic heart disease. 14499869

2003

dbSNP: rs61661343
rs61661343
0.010 GeneticVariation BEFREE Seven patients (28%) with the S143P mutation died suddenly or from progressive heart failure, or underwent heart transplantation. 15140538

2004

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1303946678
rs1303946678
0.010 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1320702652
rs1320702652
0.040 GeneticVariation BEFREE Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease. 16021915

2005

dbSNP: rs104894229
rs104894229
T 0.700 CausalMutation CLINVAR Germline mutations in HRAS proto-oncogene cause Costello syndrome. 16170316

2005