Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. 30756358

2019

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE Data from our study suggest that the β adrenoreceptor Gly 49 allele of the β1 -adrenergic receptor Ser(49) Gly polymorphisms may increase the risk of ICD shock in patients with heart failure, independent of beta-blocker dosage. 27027728

2016

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE The Ser49Gly polymorphism did not impact the risk or prognosis of HF. 22815685

2012

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression. 20803192

2010

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1801252
rs1801252
0.060 GeneticVariation BEFREE These data suggest that the beta(1)-receptor Ser49Gly variant might be associated with altered receptor function, resulting in myocardial protection in patients with heart failure. 11052857

2000