Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs141322087
rs141322087
0.700 GeneticVariation CLINVAR Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. 25741868

2015

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 23065660

2013

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE Since the pivotal role of β1 adrenergic receptor (β1-AR) in HF, many publications have studied the associations between the β1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results. 22815685

2013

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE We examined whether the Arg389Gly polymorphism in ADRβ1 interacts with the dose requirements of beta-blockers in patients with systolic HF. 23115322

2013

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients. 22617224

2012

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients. 21395649

2011

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE One study of risk for heart failure suggested a synergistic effect of ADRB1 Arg389Gly with the insertion/deletion polymorphism in the alpha2C-adrenergic receptor gene (ADRA2C). 17496726

2007

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1801253
rs1801253
0.080 GeneticVariation BEFREE An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. 12921807

2003

dbSNP: rs1799983
rs1799983
0.050 GeneticVariation BEFREE Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates. 25917853

2016

dbSNP: rs1799983
rs1799983
0.050 GeneticVariation BEFREE Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease. 25612295

2015

dbSNP: rs1799983
rs1799983
0.050 GeneticVariation BEFREE This prospective study was designed to analyze the impact of three eNOS polymorphisms (T-786C, VNTR4a/b and Glu298Asp) and their haplotypes on the susceptibility and clinical outcomes in HF outpatients with systolic dysfunction. 22290017

2012

dbSNP: rs1799983
rs1799983
0.050 GeneticVariation BEFREE Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls. 20079452

2010

dbSNP: rs1799983
rs1799983
0.050 GeneticVariation BEFREE Subjects (n = 352) in the Genetic Risk Assessment of Heart Failure (GRAHF) substudy of the African-American Heart Failure Trial were genotyped for NOS3 polymorphisms: -786 T/C promoter, intron 4a/4b, and Glu298Asp and allele frequencies and compared with a white heart failure cohort. 19327620

2009

dbSNP: rs1801252
rs1801252
0.030 GeneticVariation BEFREE The Ser49Gly polymorphism did not impact the risk or prognosis of HF. 22815685

2013

dbSNP: rs1801252
rs1801252
0.030 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1801252
rs1801252
0.030 GeneticVariation BEFREE These data suggest that the beta(1)-receptor Ser49Gly variant might be associated with altered receptor function, resulting in myocardial protection in patients with heart failure. 11052857

2001

dbSNP: rs5443
rs5443
0.020 GeneticVariation BEFREE A total of 350 subjects enrolled in the genetic substudy (GRAHF [Genetic Risk Assessment of Heart Failure in African Americans]) were genotyped for the C825T polymorphism. 25306451

2015

dbSNP: rs1042714
rs1042714
0.020 GeneticVariation BEFREE We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients. 21395649

2011

dbSNP: rs5443
rs5443
0.020 GeneticVariation BEFREE We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure (HF) using implantable cardioverter-defibrillators (ICDs). 20185488

2010

dbSNP: rs1042714
rs1042714
0.020 GeneticVariation BEFREE We investigated the clinical response of chronic heart failure patients with beta(2)-adrenergic receptor Gln(27)-->Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties.The 6-min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln(27)-->Glubeta(2)-adrenergic receptor polymorphism. 19422106

2009

dbSNP: rs1800888
rs1800888
0.020 GeneticVariation BEFREE Is there a role of the Thr164Ile-beta(2)-adrenoceptor polymorphism for the outcome of chronic heart failure? 16783489

2007

dbSNP: rs1800888
rs1800888
0.020 GeneticVariation BEFREE Of particular importance, the Thr164Ile polymorphism, which is found in approximately 4% of humans, shows decreased receptor signaling, blunted cardiac response when expressed in transgenic mice, and is associated with a decreased survival rate in patients with congestive heart failure. 11222464

2001

dbSNP: rs2306235
rs2306235
0.010 GeneticVariation BEFREE Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population. 28402261

2018

dbSNP: rs37369
rs37369
0.010 GeneticVariation BEFREE AGXT2 rs37369 polymorphism predicts the renal function in patients with chronic heart failure. 28942034

2017