rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Host DNA from all HCV positive patients and age- and sex-matched non-HCV-infected control individuals were analysed for IL28B single nucleotide polymorphism (SNP) (rs12979860 and rs8099917).
|
30865664 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms within the interferon λ (IFN-λ) chromosomal region, mainly rs12979860 of IFN-λ4 gene (IFNL4), are known as associated with spontaneous hepatitis C virus (HCV) resolution and sustained viral response to therapy with pegylated interferon- α and ribavirin.
|
30027841 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The <i>IL28B</i> rs12979860 CT/TT genotypes (OR = 3.44, 95% CI [2.12-5.58], <i>p</i> < 0.001), bAt haplotype (OR = 2.02, 95% CI [1.04-3.91], <i>p</i> = 0.03), pre-treatment serum HCV RNA (logIU/mL; OR = 1.73, 95% CI [1.31-2.28], <i>p</i> < 0.001), advanced liver fibrosis (OR = 1.68, 95% CI [1.10-2.58], <i>p</i> = 0.02), and HCV genotype 1 (OR = 1.59, 95% CI [1.07-2.37], <i>p</i> = 0.02) independently predicted poor response.
|
31565578 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most significant positive factors affecting the SC HCV included IL-28B single nucleotide polymorphism (SNP) rs12979860 (CC) and SNP rs8099917 (TT) (OR 4.03, p<0.001) and (OR 3.14, p<0.002), female gender (OR 2.72, p<0.001), young age (OR 2.30, p<0.008), and past history of jaundice (OR 5.12, p<0.001).
|
31060998 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Besides normal routine laboratory testing for HCV, patients' sera were evaluated also for retinol, retinol-binding protein 4 and the following SNPs: PNPLA3 (rs738409), TM6SF2 (rs58542926), MBOAT7 (rs641738), IL28B (rs12979860), TIMP-1 (rs4898), TIMP-2 (rs8179090), NF-kB promoter (rs28362491).
|
31826071 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis indicated that cholesterol, triglyceride, low-density lipoprotein, 25-hydroxyvitamin D, platelets, duration of hemodialysis, HCV subtypes, IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ΔG/ΔG genotypes were associated with OCI.
|
30821879 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of treatment response showed that CC (major) genotype of IFNL3 (rs12979860) and TT (major) genotype of IFNL3 (rs8099917) are associated with the likelihood of achieving a higher sustained virological response (SVR), to combined daclatasvir and sofosbuvir therapy, in genotype 3-infected HCV patients, whereas the individuals with TT (minor) genotype of IFNL3 (rs12979860) and GG (minor) genotype of IFNL3 (rs8099917) are more susceptible to chronic HCV infection and treatment relapse, suggesting a role of IFNL3 (rs12979860) and (rs8099917) in the treatment outcome of combined daclatasvir and sofosbuvir therapy in chronic HCV genotype 3 infection.
|
30431653 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Introduction:</b> IFNL4 rs12979860 genotype CC is associated with increased ALT activity and liver stiffness in hepatitis C virus (HCV) genotype (G) 3 infection but not in G1.
|
31479286 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sensitivity analyses suggested the robustness of the results in this meta-analysis.Both IL28B rs12979860 CC and rs8099917 TT genotypes are protective factors for the development of HCC among patients with HBV or HCV infection.
|
31568008 |
2019 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also found that the rs12979860, rs2227982 and rs36084323 polymorphisms showed no significant associations with susceptibility or spontaneous clearance of HCV in the anti-F antibody subgroup; however, the anti-F antibody positive subgroup might show an increased risk of N-SVR (all P < 0.001).
|
29399747 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<i>IL28B</i> C/T polymorphism (rs12979860) was evaluated in circulating blood cells using a PCR-based restriction fragment length polymorphism assay.Overall <i>H. pylori</i> serology was positive in 38.1% of our HCV-infected subjects.
|
29510558 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Predictive value of IL-28B rs12979860 variants for peg-IFN, sofosbuvir plus ribavirin treatment of HCV infection in Pakistani population.
|
30383478 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with HCV infection have a statistically significant lower prevalence of the favourable rs12979860 genotype when compared to uninfected individuals; therefore we can establish that only IL28B rs12979860-CT and TT genotypes seem to contribute to the occurrence of chronic HCV infection in the cohort of Uruguayan population studied.
|
29499724 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multinominal logistic regression analyses revealed that both genders favor IL28B rs12979860 CT genotype (OR: 4.80; CI: 2.22-10.35; p = 0.0005) and (OR: 3.47; CI: 1.63-7.43; p = 0.001) for male and female, respectively, are significant in spontaneous clearance of HCV infection.
|
30398404 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B single nucleotide polymorphism (rs12979860) is an etiology-independent predictor of hepatitis C virus (HCV)-related hepatic fibrosis.
|
29279441 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL-28B rs12979860 polymorphism affect the course of chronic hepatitis and the development of HCC in Egyptian patients with hepatitis C type 4.
|
29914308 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HCV g6-infected rs12979860 major homozygous individuals had significantly higher viral loads than individuals with minor alleles (CC: 6.56 log IU/ml vs. non-CC: 5.66 log IU/ml; P = 0.021).
|
29022122 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B (rs8099917 and rs12979860) and IL10 (rs1800896) polymorphisms alone, or in combination, are good predictors of therapeutic response in HCV-3a patients.
|
29340806 |
2018 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single genetic nucleotide polymorphism (rs12979860) near the gene for interleukin 28B (IL28B) is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon-based therapies in patients with hepatitis C virus (HCV) infection.
|
28820758 |
2017 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 557 HCV-seroreactive individuals with thalassemia were processed for HCV viral genotyping and host IL28B single-nucleotide polymorphism analysis at loci rs12979860 and rs8099917.
|
28419488 |
2017 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of interleukin-28B rs12979860 and rs8099917 polymorphisms with sustained viral response in hepatitis C virus genotype 1 and 3 infected patients from the Indian subcontinent.
|
27514956 |
2017 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 710 people with diagnosed hepatitis C virus were examined in order to determine the distribution of polymorphisms of gene IL28B rs12979860, rs8099917 and rs12980275.
|
29264884 |
2017 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HCV genotype (P=0.007), IFNL3 rs12979860 (CC) (P=0.023), IFNL3 rs12980275 (AA) (P=1 × 10<sup>-4</sup>), EGFR rs11506105 (AA) (P=0.005), RVR (P=1 × 10<sup>-4</sup>), and cEVR (P=0.003) were significant predictors for SVR.
|
28703131 |
2017 |
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease.
|
28513591 |
2017 |