|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We investigated individual and combined associations of Pro12Ala and His447His polymorphisms of PPARγ with PCOS susceptibility and its related traits (hyperinsulinemia, hyperandrogenemia and lipid parameters) in Indian women.
|
23748472 |
2013 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Pro12Ala, a missense mutation in exon 2 of PPARG, reduces transcriptional activity of PPARgamma2 and is shown to be associated with increased insulin sensitivity and protection from T2D.
|
20368233 |
2010 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We studied the effect of the Pro12Ala polymorphism on the rates of whole-body, skeletal muscle, and subcutaneous adipose tissue glucose uptake (GU) in T2DM subjects, and the rates of hepatic GU in nondiabetic and T2DM subjects during hyperinsulinemia.
|
19303976 |
2009 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women.
|
15853827 |
2005 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes.
|
12643137 |
2002 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results suggest that the Pro12Ala polymorphism of the PPARgamma-2 gene promotes peripheral deposition of adipose tissue and increased insulin sensitivity for a given BMI.
|
12370112 |
2002 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism in the PPAR-gamma2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo.
|
11334419 |
2001 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis.
|
11684868 |
2001 |
|
rs1805192
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects.
|
10382597 |
1999 |