DisGeNET - a database of gene-disease associations

Irritable Bowel Syndrome, C0022104

Variant: rs4680 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs4680

COMT ; MIR4761

0.030

GeneticVariation

BEFREE

COMT Val158Met Polymorphism and Symptom Improvement Following a Cognitively Focused Intervention for Irritable Bowel Syndrome.

28252569

2017

dbSNP:

rs4680

COMT ; MIR4761

0.030

GeneticVariation

BEFREE

In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035).

23110189

2012

dbSNP:

rs4680

COMT ; MIR4761

0.030

GeneticVariation

BEFREE

In this study we found an association between the val/val genotype of the val158met COMT gene and IBS as well as to specific IBS related bowel pattern in IBS patients.

21437260

2011