rs9999118
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
|
24797007 |
2014 |
rs9999118
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
|
24797007 |
2014 |
rs5443
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In elderly Chinese patients, the 158Met SNP in COMT is associated with IBS pathogenesis, but the GNβ3-C825T SNP is not associated with IBS pathogenesis.
|
25037115 |
2014 |
rs5443
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present study suggests no associations of GNB3 C825T polymorphism with IBS risk.
|
24876757 |
2014 |
rs5443
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We evaluated the association of the GNB3 C825T polymorphism with GERD and GERD subgroups classified according to esophageal acid exposure time, symptom-reflux correlation, or coexistence of FD and/or irritable bowel syndrome (IBS) symptoms.
|
19174793 |
2009 |
rs5443
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Whereas no specific gene has been identified in association with IBS, recent studies have noticed the importance of polymorphisms in the promoter region of the serotonin reuptake transporter gene, G-protein beta 3 subunit gene (C825T), cholecystokinin receptor (CCKAR gene 779T>C), and high-producer tumor necrosis factor genotype.
|
19034965 |
2008 |
rs4263839
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients.
|
31615448 |
2019 |
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
COMT Val158Met Polymorphism and Symptom Improvement Following a Cognitively Focused Intervention for Irritable Bowel Syndrome.
|
28252569 |
2017 |
rs7209436
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS.
|
26808377 |
2016 |
rs7209436
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Three CRH-R1 SNPS (rs110402, rs242924, and rs7209436) were genotyped using salivary DNA from IBS and healthy control subjects (HCs).
|
27497153 |
2016 |
rs4263839
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our meta-analysis could not confirm a major role of most investigated SNPs, but a moderate association between rs4263839 TNFSF15 and IBS, in particular IBS-C.
|
25824902 |
2015 |
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035).
|
23110189 |
2012 |
rs7209436
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls.
|
22957021 |
2012 |
rs4263839
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The Crohn's disease risk allele rs4263839 G in the TNFSF15 gene was significantly associated with an increased risk of both IBS (p=2.2×10(-5); OR 1.37) and more pronouncedly, IBS-C (p=8.7×10(-7); OR 1.79) in the entire sample.
|
21636646 |
2011 |
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study we found an association between the val/val genotype of the val158met COMT gene and IBS as well as to specific IBS related bowel pattern in IBS patients.
|
21437260 |
2011 |
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients.
|
31615448 |
2019 |
rs1800871
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study.
|
31615448 |
2019 |
rs1800896
|
|
|
0.020 |
GeneticVariation |
BEFREE |
IL-10 rs1800896 C allele is correlated with higher IL-10 levels in the plasma and the PBMC culture supernatant, which is associated with a higher pain threshold in the Chinese patients with IBS-D.
|
31205078 |
2019 |
rs1800896
|
|
|
0.020 |
GeneticVariation |
BEFREE |
It was confirmed that polymorphisms of TNFSF15 associated with increased IBS risk, while IL10 rs1800896 associated with decreased IBS risk.
|
31615448 |
2019 |
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To address this inconsistency, we conducted the current systematic review and meta-analysis on serum/plasma IL-6 levels and IL-6 (-G174C; rs1800795) gene polymorphism in IBS.
|
28886490 |
2017 |
rs242924
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS.
|
26808377 |
2016 |
rs324420
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variation in the (AAT)n repeat of the CNR1 gene conferred an increased risk for developing IBS, while rs324420 (C385) in the FAAH gene was not associated with IBS pathogenesis.
|
24444427 |
2014 |
rs1800871
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no significant associations are found between rs1800871 and IBS risk.
|
24409078 |
2013 |
rs806378
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was significant association of CNR1 rs806378 (P = 0.014; CC vs. CT/TT) with colonic transit in IBS-diarrhea (IBS-D) group; the TT group had the fastest colonic transit at 24 and 48 h. There was significant overall association of CNR1 rs806378 with sensation rating of gas (P = 0.025), but not pain; the strongest associations for gas ratings were in IBS-D (P = 0.002) and IBS-alternating (P = 0.025) subgroups.
|
23306084 |
2013 |
rs242924
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls.
|
22957021 |
2012 |