Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9999118
rs9999118
G 0.800 GeneticVariation GWASDB Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. 24797007

2014

dbSNP: rs9999118
rs9999118
G 0.800 GeneticVariation GWASCAT Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. 24797007

2014

dbSNP: rs5443
rs5443
0.040 GeneticVariation BEFREE In elderly Chinese patients, the 158Met SNP in COMT is associated with IBS pathogenesis, but the GNβ3-C825T SNP is not associated with IBS pathogenesis. 25037115

2014

dbSNP: rs5443
rs5443
0.040 GeneticVariation BEFREE The present study suggests no associations of GNB3 C825T polymorphism with IBS risk. 24876757

2014

dbSNP: rs5443
rs5443
0.040 GeneticVariation BEFREE We evaluated the association of the GNB3 C825T polymorphism with GERD and GERD subgroups classified according to esophageal acid exposure time, symptom-reflux correlation, or coexistence of FD and/or irritable bowel syndrome (IBS) symptoms. 19174793

2009

dbSNP: rs5443
rs5443
0.040 GeneticVariation BEFREE Whereas no specific gene has been identified in association with IBS, recent studies have noticed the importance of polymorphisms in the promoter region of the serotonin reuptake transporter gene, G-protein beta 3 subunit gene (C825T), cholecystokinin receptor (CCKAR gene 779T>C), and high-producer tumor necrosis factor genotype. 19034965

2008

dbSNP: rs4263839
rs4263839
0.030 GeneticVariation BEFREE Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. 31615448

2019

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE COMT Val158Met Polymorphism and Symptom Improvement Following a Cognitively Focused Intervention for Irritable Bowel Syndrome. 28252569

2017

dbSNP: rs7209436
rs7209436
0.030 GeneticVariation BEFREE Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS. 26808377

2016

dbSNP: rs7209436
rs7209436
0.030 GeneticVariation BEFREE Three CRH-R1 SNPS (rs110402, rs242924, and rs7209436) were genotyped using salivary DNA from IBS and healthy control subjects (HCs). 27497153

2016

dbSNP: rs4263839
rs4263839
0.030 GeneticVariation BEFREE Our meta-analysis could not confirm a major role of most investigated SNPs, but a moderate association between rs4263839 TNFSF15 and IBS, in particular IBS-C. 25824902

2015

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). 23110189

2012

dbSNP: rs7209436
rs7209436
0.030 GeneticVariation BEFREE The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls. 22957021

2012

dbSNP: rs4263839
rs4263839
0.030 GeneticVariation BEFREE The Crohn's disease risk allele rs4263839 G in the TNFSF15 gene was significantly associated with an increased risk of both IBS (p=2.2×10(-5); OR 1.37) and more pronouncedly, IBS-C (p=8.7×10(-7); OR 1.79) in the entire sample. 21636646

2011

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE In this study we found an association between the val/val genotype of the val158met COMT gene and IBS as well as to specific IBS related bowel pattern in IBS patients. 21437260

2011

dbSNP: rs1800795
rs1800795
0.020 GeneticVariation BEFREE Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. 31615448

2019

dbSNP: rs1800871
rs1800871
0.020 GeneticVariation BEFREE No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study. 31615448

2019

dbSNP: rs1800896
rs1800896
0.020 GeneticVariation BEFREE IL-10 rs1800896 C allele is correlated with higher IL-10 levels in the plasma and the PBMC culture supernatant, which is associated with a higher pain threshold in the Chinese patients with IBS-D. 31205078

2019

dbSNP: rs1800896
rs1800896
0.020 GeneticVariation BEFREE It was confirmed that polymorphisms of TNFSF15 associated with increased IBS risk, while IL10 rs1800896 associated with decreased IBS risk. 31615448

2019

dbSNP: rs1800795
rs1800795
0.020 GeneticVariation BEFREE To address this inconsistency, we conducted the current systematic review and meta-analysis on serum/plasma IL-6 levels and IL-6 (-G174C; rs1800795) gene polymorphism in IBS. 28886490

2017

dbSNP: rs242924
rs242924
0.020 GeneticVariation BEFREE Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS. 26808377

2016

dbSNP: rs324420
rs324420
0.020 GeneticVariation BEFREE The variation in the (AAT)n repeat of the CNR1 gene conferred an increased risk for developing IBS, while rs324420 (C385) in the FAAH gene was not associated with IBS pathogenesis. 24444427

2014

dbSNP: rs1800871
rs1800871
0.020 GeneticVariation BEFREE However, no significant associations are found between rs1800871 and IBS risk. 24409078

2013

dbSNP: rs806378
rs806378
0.020 GeneticVariation BEFREE There was significant association of CNR1 rs806378 (P = 0.014; CC vs. CT/TT) with colonic transit in IBS-diarrhea (IBS-D) group; the TT group had the fastest colonic transit at 24 and 48 h. There was significant overall association of CNR1 rs806378 with sensation rating of gas (P = 0.025), but not pain; the strongest associations for gas ratings were in IBS-D (P = 0.002) and IBS-alternating (P = 0.025) subgroups. 23306084

2013

dbSNP: rs242924
rs242924
0.020 GeneticVariation BEFREE The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls. 22957021

2012