Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs219780
rs219780
0.810 GeneticVariation BEFREE In conclusion, rs1801725, rs1042636, rs219778 and rs219780 SNPs were associated with kidney stone risk in patients from the eastern part of India. 26107257

2015

dbSNP: rs219780
rs219780
C 0.810 GeneticVariation GWASCAT Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. 19561606

2009

dbSNP: rs219780
rs219780
C 0.810 GeneticVariation GWASDB Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. 19561606

2009

dbSNP: rs12654812
rs12654812
0.740 GeneticVariation BEFREE In addition, subjects carrying the minor AA genotype at rs12654812 (regulator of G protein signaling 14 (RGS14)) have higher susceptibility to nephrolithiasis (OR = 1.91, p = 0.0017). 31754202

2019

dbSNP: rs12654812
rs12654812
0.740 GeneticVariation BEFREE The A allele of rs12654812</span> significantly increased the risk of nephrolithiasis co</span>mpared with the G allele after adjusting for age, sex, BMI, smoking, drinking and hypertension (OR = 1.277, 95% CI = 1.013-1.609, P = .038). 29577426

2018

dbSNP: rs12654812
rs12654812
0.740 GeneticVariation BEFREE We selected single-nucleotide polymorphism (SNPs) including rs12654812 and rs11746443 from 5q32.3; rs12669187 and rs1000597 from 7q14.3; rs7981733, rs4142110 and rs17646069 from 13q14.1 and rs4293393 from 16p12.3 which were previously reported to be associated with nephrolithiasis. 28361944

2017

dbSNP: rs12654812
rs12654812
A 0.740 GeneticVariation GWASCAT Common and rare variants associated with kidney stones and biochemical traits. 26272126

2015

dbSNP: rs12654812
rs12654812
0.740 GeneticVariation BEFREE We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis. rs12654812, rs12669187 and rs7981733 were significantly associated with nephrolithiasis after Bonferroni's correction (P=3.12 × 10(-3), odds ratio (OR)=1.43; P=6.40 × 10(-3), OR=1.57; and P=5.00 × 10(-3), OR=1.41, respectively). 23719187

2013

dbSNP: rs1256328
rs1256328
0.720 GeneticVariation BEFREE In summary, this study successfully validated the genetic roles of rs1256328 and rs12654812 in human nephrolithiasis. 31754202

2019

dbSNP: rs1256328
rs1256328
0.720 GeneticVariation BEFREE The ALPL SNP, rs1256328, was identified as being significantly associated with kidney stone disease status in a large Chinese Han cohort. 29489416

2018

dbSNP: rs1256328
rs1256328
T 0.720 GeneticVariation GWASCAT Common and rare variants associated with kidney stones and biochemical traits. 26272126

2015

dbSNP: rs219778
rs219778
0.710 GeneticVariation BEFREE In conclusion, rs1801725, rs1042636, rs219778 and rs219780 SNPs were associated with kidney stone risk in patients from the eastern part of India. 26107257

2015

dbSNP: rs219778
rs219778
0.710 GeneticVariation GWASDB Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. 19561606

2009

dbSNP: rs199565725
rs199565725
AAC 0.700 GeneticVariation GWASCAT Common and rare variants associated with kidney stones and biochemical traits. 26272126

2015

dbSNP: rs7627468
rs7627468
A 0.700 GeneticVariation GWASCAT Common and rare variants associated with kidney stones and biochemical traits. 26272126

2015

dbSNP: rs219781
rs219781
0.700 GeneticVariation GWASDB Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. 19561606

2009

dbSNP: rs1042636
rs1042636
0.060 GeneticVariation BEFREE Activating rs1042636 polymorphism located in exon 7 was associated with calcium nephrolithiasis and hypercalciuria. 30446806

2019

dbSNP: rs7652589
rs7652589
0.060 GeneticVariation BEFREE Epidemiological studies observed that calcium nephrolithiasis was associated with polymorphisms of the CaSR gene regulatory region, rs6776158, located within the promoter-1, rs1501899 located in the intron 1, and rs7652589 in the 5'-untranslated region. 30446806

2019

dbSNP: rs7652589
rs7652589
0.060 GeneticVariation BEFREE CASR rs7652589_rs1801725 AG haplotype was 1.5-fold more frequent in nephrolithiasis-related ESRD than the GG haplotype (P = 0.004). 29763933

2018

dbSNP: rs7652589
rs7652589
0.060 GeneticVariation BEFREE Our study showed that CaSR rs7652589 polymorphism had a significant effect on the risk of developing calcium nephrolithiasis in the population of Yi nationality in Southwestern China. 29682741

2018

dbSNP: rs1042636
rs1042636
0.060 GeneticVariation BEFREE Our results provide evidences that the CaSR Arg990Gly polymorphism is associated with the risk of nephrolithiasis development in a Chinese population. 28609763

2017

dbSNP: rs7652589
rs7652589
0.060 GeneticVariation BEFREE Associations of the calcium-sensing receptor gene CASR rs7652589 SNP with nephrolithiasis and secondary hyperparathyroidism in haemodialysis patients. 27739473

2016

dbSNP: rs1042636
rs1042636
0.060 GeneticVariation BEFREE We conclude that the simultaneous presence of the minor allele at rs1501899 and Arg990Gly may amplify the kidney stone risk in PHPT patients, despite their apparently opposite effects on CASR function in the kidney. 24832896

2015

dbSNP: rs1042636
rs1042636
0.060 GeneticVariation BEFREE In conclusion, rs1801725, rs1042636, rs219778 and rs219780 SNPs were associated with kidney stone risk in patients from the eastern part of India. 26107257

2015

dbSNP: rs1042636
rs1042636
0.060 GeneticVariation BEFREE The activating Arg990Gly polymorphism may predispose to nephrolithiasis by increasing calcium excretion. 22660550

2012