|
rs17235409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that rs17235409 (D543N) and rs17235416 (1729 + 55del4) are significantly associated with a risk for cutaneous leishmaniasis (CL), whereas rs17221959, rs2279015, and rs17235409 are associated with visceral leishmaniasis (VL).
|
31230160 |
2019 |
|
rs17235409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicated that genetic variations of D543N (rs17235409) might be associated with susceptibility to CL infection.
|
27681549 |
2017 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60).
|
24282567 |
2013 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotyping for Asp299Gly and Thr399Ile was performed in patients with chronic (N = 22) and acute (N = 61) CL, asymptomatic (N = 45) and healthy leishmanin skin test negative individuals (N = 75).
|
21056683 |
2011 |
|
rs13900
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in regulatory regions of the <i>CCL2</i> promoter were analyzed in a pilot cohort of DNA samples from CL patients (cures n=20 and treatment failure n=20), showing putative association of rs13900(C/T) and rs2857656(G/C) with treatment outcome.
|
31818959 |
2020 |
|
rs1143634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs -511T/C (rs16944) and +3954C/T (rs1143634) of the IL1B and IL1RN VNTR (rs2234663) were assessed in 881 patients with CL and 837 healthy controls by PCR-RFLP and direct PCR respectively.
|
31357078 |
2019 |
|
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs16944 C/C genotype was more common among the patients (OR = 1.5 [95%CI 1.1-2.0]; P = 0.004) and the C allele suggests susceptibility to CL (OR = 1.2 [95%CI 1.1-1.4]; P = 0.003).
|
31357078 |
2019 |
|
rs17221959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs17235409 (D543N) and rs17235416 (1729 + 55del4) are significantly associated with a risk for cutaneous leishmaniasis (CL), whereas rs17221959, rs2279015, and rs17235409 are associated with visceral leishmaniasis (VL).
|
31230160 |
2019 |
|
rs17235416
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs17235409 (D543N) and rs17235416 (1729 + 55del4) are significantly associated with a risk for cutaneous leishmaniasis (CL), whereas rs17221959, rs2279015, and rs17235409 are associated with visceral leishmaniasis (VL).
|
31230160 |
2019 |
|
rs2069705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IFNG variant rs2069705 seems to be a genetic modifier of clinical outcome of Leishmania infection; individuals with the H1 haplotype, associated with low levels of IFN-γ, have a 60% risk of developing CL.
|
31722386 |
2019 |
|
rs2234663
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs -511T/C (rs16944) and +3954C/T (rs1143634) of the IL1B and IL1RN VNTR (rs2234663) were assessed in 881 patients with CL and 837 healthy controls by PCR-RFLP and direct PCR respectively.
|
31357078 |
2019 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we investigated the association of the rs2275913 SNP (G/A) from IL-17A and two forms of susceptibility to CL in Brazil by case-control study.
|
31344596 |
2019 |
|
rs2279015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs17235409 (D543N) and rs17235416 (1729 + 55del4) are significantly associated with a risk for cutaneous leishmaniasis (CL), whereas rs17221959, rs2279015, and rs17235409 are associated with visceral leishmaniasis (VL).
|
31230160 |
2019 |
|
rs3750920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G and T alleles of the rs5743899 and rs3750920 were more common in patients with CL than in healthy individuals (P = 2.6 x10(-8) ; odds ratio [OR], 1.7 [ 95% confidence interval (CI) 1.4-2.0] and P = 1.9 x10(-8) ; OR, 1.6 [95% CI 1.4-1.9] respectively).
|
26107286 |
2015 |
|
rs5743899
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G and T alleles of the rs5743899 and rs3750920 were more common in patients with CL than in healthy individuals (P = 2.6 x10(-8) ; odds ratio [OR], 1.7 [ 95% confidence interval (CI) 1.4-2.0] and P = 1.9 x10(-8) ; OR, 1.6 [95% CI 1.4-1.9] respectively).
|
26107286 |
2015 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for Asp299Gly and Thr399Ile was performed in patients with chronic (N = 22) and acute (N = 61) CL, asymptomatic (N = 45) and healthy leishmanin skin test negative individuals (N = 75).
|
21056683 |
2011 |
|
rs7930515
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Robust case-pseudocontrol logistic regression analysis showed association between allele C (odds ratio (OR) 1.65; 95% confidence interval 1.18-2.29; P=0.003) of FLI1_rs7930515 and CL in the primary sample that was confirmed (OR 1.60; 95% confidence interval 1.10-2.33; P=0.014) in the replication set (combined P=1.8 × 10(-4)).
|
21633373 |
2011 |
|
rs121917864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the frequency of Arg753Gln and Arg677Trp polymorphisms of TLR2 in patients with cutaneous leishmaniasis (CL) compared to healthy controls.
|
20388552 |
2010 |
|
rs5743708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lack of association of Toll-Like Receptor 2 Arg753Gln with cutaneous leishmaniasis.
|
20388552 |
2010 |