Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs786205155
rs786205155
0.710 GeneticVariation BEFREE Here we identify a novel germline ETV6 p. L349P mutation in a kindred affected by thrombocytopenia and ALL. 26102509

2015

dbSNP: rs786205155
rs786205155
C 0.710 CausalMutation CLINVAR

dbSNP: rs121909646
rs121909646
A 0.700 CausalMutation CLINVAR

dbSNP: rs121913488
rs121913488
A 0.700 CausalMutation CLINVAR

dbSNP: rs587776834
rs587776834
A 0.700 CausalMutation CLINVAR

dbSNP: rs587782545
rs587782545
NBN
A 0.700 CausalMutation CLINVAR

dbSNP: rs63750250
rs63750250
AT 0.700 CausalMutation CLINVAR

dbSNP: rs730881864
rs730881864
NBN
A 0.700 GeneticVariation CLINVAR

dbSNP: rs752746786
rs752746786
T 0.700 CausalMutation CLINVAR

dbSNP: rs767215758
rs767215758
NBN
A 0.700 CausalMutation CLINVAR

dbSNP: rs767454740
rs767454740
NBN
G 0.700 GeneticVariation CLINVAR

dbSNP: rs786205154
rs786205154
A 0.700 CausalMutation CLINVAR

dbSNP: rs869312821
rs869312821
C 0.700 CausalMutation CLINVAR

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL. 30545275

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia. 31499477

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models. 31188929

2019

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models. 31188929

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia. 29911750

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility. 28062297

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE There were no associations between MTHFR C677T or MTHFR A1298C polymorphisms and ALL susceptibility. 28646637

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014). 29390492

2017

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014). 29390492

2017

dbSNP: rs397507444
rs397507444
0.100 GeneticVariation BEFREE There were no associations between MTHFR C677T or MTHFR A1298C polymorphisms and ALL susceptibility. 28646637

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL. 25115513

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model. 25099492

2015