|
rs61754966
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A rare polymorphic variant of NBS1 that resulted in an isoleucine to valine substitution at amino acid position 171 (I171V) was first identified in childhood acute lymphoblastic leukemia.
|
24830725 |
2014 |
|
rs61754966
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In our previous study we showed that the germline p.I171V mutation in NBN may be considered as a risk factor in the development of childhood acute lymphoblastic leukemia (ALL) and some specific haplotypes of that gene may be associated with childhood leukemia.
|
24093751 |
2013 |
|
rs61754966
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs12721593
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs61753720
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the studied Egyptian population, it can be concluded that the C allele, CC, and CT genotypes of <i>ARID5B</i> rs10821936 and the CA haplotype may be a susceptibility risk factor for pediatric and adult ALL.
|
31424309 |
2019 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 5,10-MTHFR 677C>T and RFC1 80G>A polymorphisms are associated with an increased risk of susceptibility to pediatric ALL.
|
31499477 |
2019 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL.
|
30545275 |
2019 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.
|
31604453 |
2019 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Metaanalysis results showed no significant association between C3435T polymorphism and pediatric ALL risk (TT vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95-1.52; CT vs. CC: OR = 1.00, 95% CI = 0.82-1.23; the dominant model: OR = 1.07, 95% CI = 0.89-1.29; the recessive model: OR = 1.17, 95% CI = 0.84-1.62).
|
28845766 |
2017 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7.
|
28817678 |
2017 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, <i>MTHFR</i> C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL.
|
28392709 |
2017 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014).
|
29390492 |
2017 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014).
|
29390492 |
2017 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, <i>MTHFR</i> C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL.
|
28392709 |
2017 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a borderline association was found between IKZF1 rs4132601 T>G variant and ALL risk.
|
28768142 |
2017 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively).
|
28476190 |
2016 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the rs4132601 G allele increased the risk of ALL (OR = 1.86, 95 % CI = 1.28-2.96; p = 0.0011) in comparison with the T allele.
|
26790447 |
2016 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results, which are consistent with findings in European populations, show that 3 SNPs, i.e., rs4132601 (P = .00116, odds ratio [OR] = 2.78, 95% confidence interval [CI] = [1.42, 5.87]), rs7089424 (P = .0022, OR = 0.49, 95% CI = [0.31, 0.79]), and rs2239633 (P = .0010, OR = 0.47, 95% CI = [0.29, 0.75]) are significantly associated with a higher risk of developing pediatric ALL (P < .05).
|
27184773 |
2016 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
|
25854371 |
2015 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
|
25661341 |
2015 |