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rs1057520016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study provides clues in understanding structural basis of T875N mutation caused JAK2 hyperactivation and its roles in the pathology of AML.
|
31299252 |
2019 |
|
rs111394117
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For patients with AML, the increased risk of post-HSCT relapse was associated with the donor SNP of rs111394117 in the intron of NOTCH4 gene, and the recipient SNPs of rs213210 in the ring finger protein 1 (RING1) gene promoter, and rs17220087 and rs17213693 in the intron of HLA-DOB gene.
|
31551439 |
2019 |
|
rs1178981336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
γH2AX immunofluorescent staining assay revealed increased DNA damage in a human acute myeloid leukemia (AML) cell line ectopically expressing HLTF E259K, which was not observed in cells expressing wild-type HLTF.
|
30696947 |
2019 |
|
rs138817062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, little is known about the underlying mechanisms by which HIPK2 mutations are associated with the pathogenesis of leukemia.
|
30755814 |
2019 |
|
rs142269166
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Detected variants occurred at higher than expected frequencies in patients with MPNs and AML in comparison with the population, and N1108S had a significantly increased prevalence in patients with AML.
|
30811597 |
2019 |
|
rs150008607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the biologic significance of novel MYH8 tail truncation mutation, R1292X in acute myeloid leukemia (AML) which discovered by whole-exome sequencing and targeted re-sequencing of 209 AML patients.
|
31430364 |
2019 |
|
rs17213693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For patients with AML, the increased risk of post-HSCT relapse was associated with the donor SNP of rs111394117 in the intron of NOTCH4 gene, and the recipient SNPs of rs213210 in the ring finger protein 1 (RING1) gene promoter, and rs17220087 and rs17213693 in the intron of HLA-DOB gene.
|
31551439 |
2019 |
|
rs17220087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For patients with AML, the increased risk of post-HSCT relapse was associated with the donor SNP of rs111394117 in the intron of NOTCH4 gene, and the recipient SNPs of rs213210 in the ring finger protein 1 (RING1) gene promoter, and rs17220087 and rs17213693 in the intron of HLA-DOB gene.
|
31551439 |
2019 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to evaluate the multivariate effect of TNF-α rs361525, rs1800750, rs1800629, IL-10 rs1800896, rs1800872, IL-6 rs1800795, TGF-β1 rs1800470, IFN-γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML.
|
31373163 |
2019 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to evaluate the multivariate effect of TNF-α rs361525, rs1800750, rs1800629, IL-10 rs1800896, rs1800872, IL-6 rs1800795, TGF-β1 rs1800470, IFN-γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML.
|
31373163 |
2019 |
|
rs1800750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Age above 65 years, PLT count, TNF-α rs1800750 variant genotype, blast percentage, LDH level, and cytogenetic high-risk may be used as independent risk factors to assess AML mortality.
|
31373163 |
2019 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to evaluate the multivariate effect of TNF-α rs361525, rs1800750, rs1800629, IL-10 rs1800896, rs1800872, IL-6 rs1800795, TGF-β1 rs1800470, IFN-γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML.
|
31373163 |
2019 |
|
rs213210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For patients with AML, the increased risk of post-HSCT relapse was associated with the donor SNP of rs111394117 in the intron of NOTCH4 gene, and the recipient SNPs of rs213210 in the ring finger protein 1 (RING1) gene promoter, and rs17220087 and rs17213693 in the intron of HLA-DOB gene.
|
31551439 |
2019 |
|
rs2279744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the role of MDM2 -309T>G (rs2279744) polymorphism in AML remains unclear.
|
31653152 |
2019 |
|
rs2393726
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It was found that the association of <i>ARID5B</i> polymorphisms with AML was most significant in acute promyelocytic leukemia (APL), and exclusively in males, the mutant alleles of rs6415872, rs2393726, rs7073837, rs10821936, and rs7089424 were found to increase the risk of developing APL in men, the odds ratio (OR) were 1.36, 1.74, 1.45, 1.53, and 1.56 (all <i>p</i> < 0.05), respectively.
|
31599655 |
2019 |
|
rs2430561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia.
|
31373163 |
2019 |
|
rs3901533
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, two Dectin-1 SNPs (rs3901533 and rs7309123) are associated with increased susceptibility to pulmonary IFD in AML patients in a Chinese Han population.
|
31845221 |
2019 |
|
rs6415872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It was found that the association of <i>ARID5B</i> polymorphisms with AML was most significant in acute promyelocytic leukemia (APL), and exclusively in males, the mutant alleles of rs6415872, rs2393726, rs7073837, rs10821936, and rs7089424 were found to increase the risk of developing APL in men, the odds ratio (OR) were 1.36, 1.74, 1.45, 1.53, and 1.56 (all <i>p</i> < 0.05), respectively.
|
31599655 |
2019 |
|
rs7073837
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It was found that the association of <i>ARID5B</i> polymorphisms with AML was most significant in acute promyelocytic leukemia (APL), and exclusively in males, the mutant alleles of rs6415872, rs2393726, rs7073837, rs10821936, and rs7089424 were found to increase the risk of developing APL in men, the odds ratio (OR) were 1.36, 1.74, 1.45, 1.53, and 1.56 (all <i>p</i> < 0.05), respectively.
|
31599655 |
2019 |
|
rs7089424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It was found that the association of <i>ARID5B</i> polymorphisms with AML was most significant in acute promyelocytic leukemia (APL), and exclusively in males, the mutant alleles of rs6415872, rs2393726, rs7073837, rs10821936, and rs7089424 were found to increase the risk of developing APL in men, the odds ratio (OR) were 1.36, 1.74, 1.45, 1.53, and 1.56 (all <i>p</i> < 0.05), respectively.
|
31599655 |
2019 |
|
rs759272576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Targeted next-generation sequencing at the time of AML progression on gilteritinib identified treatment-emergent mutations that activate RAS/MAPK pathway signaling, most commonly in <i>NRAS</i> or <i>KRAS.</i> Less frequently, secondary <i>FLT3</i>-F691L gatekeeper mutations or <i>BCR-ABL1</i> fusions were identified at progression.
|
31088841 |
2019 |
|
rs76208147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Survival analysis indicated that SETD2 rs76208147 TT genotype was significantly associated with poor prognosis of AML (TT vs. CC + CT hazard ratio: HR = 1.838, 95% confidence interval (CI) 1.005-3.360, p = 0.048).
|
30922329 |
2019 |
|
rs782464336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In AML cohort of 239 patients, high IL2RA mRNA expression independently predicted shorter relapse free survival (RFS, p < 0.001) and overall survival (OS, p < 0.001) irrespective of age, cytogenetics, FLT3-ITD or c-KIT D816V mutational status.
|
31171000 |
2019 |
|
rs866587267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ~ 6% of acute myeloid leukemia (AML) patients that carry the fusion protein RUNX1-RUNX1T1 produced by t (8;21) (q22;q22).
|
31691804 |
2019 |
|
rs1051740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
EPHX1 rs1051740 T>C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.
|
29605894 |
2018 |