|
rs2070600
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed that haplotype T-A-G-T (allele order: rs1800625, rs1800624, rs2070600, rs184003) was significantly associated with a reduced COPD risk (OR=0.32, 95% CI: 0.06-0.60), and haplotype T-A-A-G was significantly associated with a reduced asthma risk (OR=0.19, 95% CI: 0.04-0.96).
|
31141790 |
2019 |
|
rs2070600
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The rs2070600 SNP may be associated with the development of human autoimmune disease, diabetes complications, cancer, and lung diseases such as chronic obstructive pulmonary disease and acute respiratory distress syndrome.
|
30863465 |
2019 |
|
rs2070600
|
|
|
0.760 |
GeneticVariation |
BEFREE |
COPDGene studies have revealed that some of the COPD genome-wide association study polymorphisms are strongly associated with blood biomarkers (e.g., rs2070600 in <i>AGER</i> is a pQTL [protein quantitative trait locus] for sRAGE), underscoring the importance of combining omics results.
|
30874442 |
2019 |
|
rs2070600
|
|
C |
0.760 |
GeneticVariation |
GWASCAT |
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
|
30804561 |
2019 |
|
rs2070600
|
|
C |
0.760 |
GeneticVariation |
GWASCAT |
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
|
28166215 |
2017 |
|
rs2070600
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The SNP (rs3995090) in HTR4 was associated with COPD (adjusted P = 0.022) in never-smokers, and the SNP (rs2070600) in AGER was associated with forced expiratory volume in 1 s (FEV1 %) predicted (β = -0.066, adjusted P = 0.016) and FEV1 /forced vital capacity (β = -0.071, adjusted P = 0.009) in all subjects.
|
24286382 |
2014 |
|
rs2070600
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Our study demonstrated that the frequencies of the GS genotype and the S allele in the G82S mutation were significantly higher in COPD patients than in controls (odds ratios [OR]=1.70, 95% confidence interval [CI]: 1.15-2.50, p=0.0098 and OR=1.42, 95% CI: 1.06-1.91, p=0.023, respectively).
|
24520905 |
2014 |
|
rs2070600
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).
|
22461431 |
2012 |