| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
G | 0.830 | GeneticVariation | GWASCAT | Transancestral mapping and genetic load in systemic lupus erythematosus. | 28714469 | 2017 |
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T | 0.830 | GeneticVariation | GWASCAT | Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. | 26502338 | 2015 |
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0.830 | GeneticVariation | BEFREE | Some of these SNPs affect multiple genes in trans that are known to be altered in individuals with disease: rs4917014, previously associated with systemic lupus erythematosus (SLE), altered gene expression of C1QB and five type I interferon response genes, both hallmarks of SLE. | 24013639 | 2013 |
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0.830 | GeneticVariation | BEFREE | We also explored whether the IKZF1 mRNA expression levels are associated with the variant of the SNP rs4917014 and the SLE Disease Activity Index (SLEDAI). | 20680283 | 2011 |
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0.830 | GeneticVariation | BEFREE | Significant associations were found for the single nucleotide polymorphism rs10036748 of TNIP1 with photosensitivity (odds ratio (OR) = 0.87, p = 0.01) and vasculitis (OR = 1.18, p = 0.04); rs10847697 of SLC15A4 with discoid rash (OR = 1.18, p = 0.02); rs6590330 of ETS1 with SLE of age at diagnosis <20 years (OR = 1.24, p = 8.91 x 10(-5)); rs13385731 of RasGRP3 with malar rash (OR = 1.20, p = 0.01), discoid rash (OR = 0.78, p = 0.02) and ANA (OR = 0.72, p = 0.004); rs4917014 of IKZF1 with renal nephritis (OR = 1.13, p = 0.02) and malar rash (OR = 0.83, p = 0.00038), respectively. | 20516000 | 2010 |
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A | 0.830 | GeneticVariation | GWASDB | Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. | 19838193 | 2009 |
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A | 0.830 | GeneticVariation | GWASCAT | Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. | 19838193 | 2009 |