Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs707824
rs707824
0.810 GeneticVariation BEFREE A SNP in a novel non-HLA region on 6p23 (rs707824, P(NHL) = 5.72×10(-7)) was suggestive of an association conferring susceptibility to lymphoma. 23349640

2013

dbSNP: rs11540652
rs11540652
0.720 GeneticVariation BEFREE This was associated with a twofold higher T-lymphoma proliferation in R248Q/- mice compared with G245S/- and null mice. 23538418

2013

dbSNP: rs11540652
rs11540652
0.720 GeneticVariation BEFREE We previously showed that the HSP90 inhibitor ganetespib potently suppresses T-lymphoma initiation and progression and extends overall survival (OS) in hotspot knockin mice expressing the p53 gain-of-function mutants R175H and R248Q (mutp53) by 30-59%. 28300840

2017

dbSNP: rs267601394
rs267601394
0.720 GeneticVariation BEFREE As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice. 24802772

2014

dbSNP: rs267601394
rs267601394
0.720 GeneticVariation BEFREE These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci. 27135738

2016

dbSNP: rs1057519833
rs1057519833
0.710 GeneticVariation BEFREE Herein, we identify mutation of EZH2 A677 to a glycine (A677G) among lymphoma cell lines and primary tumor specimens. 22323599

2012

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. 25768255

2015

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE Suppressing IL-10 significantly reduced STAT3 activation in both MYD88 WT and MYD88 L265P m</spa</span>n>utant lymphomas</span>. 30253331

2018

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE MYD88 L265P MUTATION DETECTION IN THE AQUEOUS HUMOR OF PATIENTS WITH VITREORETINAL LYMPHOMA. 30204732

2019

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE MYD88 L265P mutation has been reported in ∼90% of Waldenström's Macroglobulinemia (WM) patients and immunoglobulin M (IgM) monoclonal gammopathies of uncertain significance (MGUS), as well as in some cases of lymphoma and chronic lymphocytic leukemia. 24992174

2015

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE With clinical trials regarding their efficacy rapidly expanding to NHLs, we also discuss potential combinations of immune checkpoint inhibitors with the described targeted chemotherapies of L265P signaling networks, and/or with the above immunological approaches as potential ways of targeting MYD88-mutated lymphomas in the future. 30203262

2018

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE Recurrent lymphoma-associated mutations, particularly Leu265Pro (L265P), within the MyD88 Toll/interleukin-1 receptor (TIR) domain sustain lymphoma cell survival due to constitutive nuclear factor κB signaling. 25359991

2014

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE The MYD88 missense mutation c.794T>C, p.Leu265Pro, is found in patients with Waldenstörm's macroglobulinemia and lymphoma. 28042684

2017

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE In order to evaluate whether the presence of the recently described MYD88 L265P mutation in patients with Waldenström's macroglobulinemia (WM) is contributory to SS-associated lymphomagenesis, a quantitative allele-specific PCR method was performed in peripheral blood derived from 90 SS patients as well as in minor salivary gland tissues derived from 12 primary SS patients with or without lymphoma. 24153350

2014

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE Four cases of small lymphocyte-predominant benign PE from patients without history of lymphoma were examined and were all negative for MYD88 L265P mutation. 31556196

2019

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE HLA class I-restricted <i>MYD88</i> L265P-derived peptides as specific targets for lymphoma immunotherapy. 28405493

2017

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE The discovery of MYD88 L265P mutations in the vast majority of LPLs has had a major impact on the study of these lymphomas. 26454445

2016

dbSNP: rs387907272
rs387907272
0.100 GeneticVariation BEFREE IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas. 22944768

2013

dbSNP: rs397507444
rs397507444
0.050 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians. 26156333

2016

dbSNP: rs397507444
rs397507444
0.050 GeneticVariation BEFREE We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase (MTR A2756G), finding the genotype other than the MTHFR 677CC/1298AA to confer a half-risk compared to the MTHFR 677CC/1298AA and a 3-fold higher risk with the MTR GG genotype than the AA/AG genotypes. 15551285

2004

dbSNP: rs397507444
rs397507444
0.050 GeneticVariation BEFREE Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer. 16886608

2006

dbSNP: rs397507444
rs397507444
0.050 GeneticVariation BEFREE Αnalysis according to lymphoma subtype revealed increased frequency of c. 677C > T TT genotype and T allele, as well as reduced prevalence of the c. 1298A > C C allele in the pSS non-MALT group compared to controls and patients without NHL. 28779180

2017

dbSNP: rs397507444
rs397507444
0.050 GeneticVariation BEFREE C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been suggested to affect susceptibility to malignant lymphoma, possibly by altering DNA methylation. 14535593

2004

dbSNP: rs2230926
rs2230926
0.040 GeneticVariation BEFREE The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011). 24159176

2013

dbSNP: rs2230926
rs2230926
0.040 GeneticVariation BEFREE However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele. 31534975

2019