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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
5-fluorouracil (5-Fu) metabolism associated enzyme, methylenetetrahydrofolate reductase (MTHFR)'s polymorphism C677T can affect enzyme activity and a series of studies have been performed to examine the association of this MTHFR polymorphism with the clinical outcomes of gastric cancer (GC) patients treated with 5-Fu based chemotherapies.
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29581785 |
2018 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Second, MTHFR C677T polymorphism, which affects the blood homocysteine levels, was used as an instrumental variable to calculate the risk and estimate the association of gastric cancer with this single nucleotide polymorphism (SNP).
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27196483 |
2016 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We found that the MTHFR C677T polymorphism was associated with colorectal cancer (P<0.04) but not with gastric cancer.
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27823653 |
2016 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the MTHFR C677T and MTHFR A1298C polymorphisms are related to gastric cancer susceptibility in the Chinese population.
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24737431 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism is a risk factor for GC, and the A1298C polymorphism may be a protective factor against GC in eastern populations.
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25170232 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Compared with the CC genotype of MTHFR C677T, the TT genotype was significantly associated with a decreased risk of gastric cancer when the analysis was adjusted for other potential risk factors.
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24615072 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Overall, the ORs under five contrast models indicated that the MTHFR C6</span>77T variant was positively associated with gastric cancer risk (ORT vs. C = 1.21, 95% CI 1.10–1.34, P(OR) < 0.001; OR(TT vs. CC) = 1.47, 95% CI 1.22–1.76, P(OR) < 0.001; OR(TC vs. CC) = 1.20, 95% CI 1.03-1.40, P(OR) = 0.022; OR(TT + TC vs. CC) = 1.27, 95% CI 1.10-1.47, P(OR) = 0.001; OR(TT vs. CC + TC) = 1.29, 95% CI 1.15-1.46, P(OR) < 0.001).
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24122207 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
This meta-analysis supports an association between the MTHFR C677T polymorphism and increased risk of esophageal and stom</span>ach cancer, especially among Asians.
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24744129 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism was demonstrated to significantly increase the susceptibility to gastric cancer (OR(T vs. C) = 1.21, 95% CI 1.10-1.34; OR(TT vs. CC )= 1.47, 95% CI 1.22-1.76; OR(TC vs. CC )= 1.20, 95% CI 1.03-1.40; OR(TT + TC vs. CC) = 1.27, 95% CI 1.10-1.47; OR(TT vs. CC + TC )= 1.29, 95% CI 1.15-1.46), whereas no significant correlation was observed when assessing the MTHFR A1298C polymorphism (OR(C vs. A )= 1.00, 95% CI 0.90-1.10; OR(CC vs. AA) = 0.99, 95% CI 0.75-1.31; OR(CA vs. AA )= 1.01, 95% CI 0.89-1.14; OR(CC + CA vs. AA) = 1.00, 95% CI 0.89-1.13; OR(CC vs. AA + CA) = 0.97, 95% CI 0.74-1.27).
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23897558 |
2014 |
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rs397507444
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0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism was demonstrated to significantly increase the susceptibility to gastric cancer (OR(T vs. C) = 1.21, 95% CI 1.10-1.34; OR(TT vs. CC )= 1.47, 95% CI 1.22-1.76; OR(TC vs. CC )= 1.20, 95% CI 1.03-1.40; OR(TT + TC vs. CC) = 1.27, 95% CI 1.10-1.47; OR(TT vs. CC + TC )= 1.29, 95% CI 1.15-1.46), whereas no significant correlation was observed when assessing the MTHFR A1298C polymorphism (OR(C vs. A )= 1.00, 95% CI 0.90-1.10; OR(CC vs. AA) = 0.99, 95% CI 0.75-1.31; OR(CA vs. AA )= 1.01, 95% CI 0.89-1.14; OR(CC + CA vs. AA) = 1.00, 95% CI 0.89-1.13; OR(CC vs. AA + CA) = 0.97, 95% CI 0.74-1.27).
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23897558 |
2014 |
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rs397507444
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism is a risk factor for GC, and the A1298C polymorphism may be a protective factor against GC in eastern populations.
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25170232 |
2014 |
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rs397507444
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0.100 |
GeneticVariation |
BEFREE |
If neoadjuvantly treated patients were analyzed based on their tumor localization, the AC genotype of the MTHFR A1298C polymorphisms was a significant negative prognostic factor in patients with gastric cancer according to UICC 6th edition (gastric cancer including AEG type II, III: HR 2.0, 95% CI 1.3-2.0, p = 0.001) and 7th edition (gastric cancer without AEG II, III: HR 2.8, 95% CI 1.5-5.7, p = 0.003), not for AEG I.
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24490800 |
2014 |
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rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the MTHFR C677T and MTHFR A1298C polymorphisms are related to gastric cancer susceptibility in the Chinese population.
|
24737431 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran.
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23934457 |
2013 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
However, in meta-analyses odds ratio for MTHFR c.677C>T homozygotes versus noncarriers were 1.07 (95% CI: 1.01-1.12) for any cancer, 1.77 (1.17-2.68) for esophagus cancer, 1.40 (1.19-1.66) for gastric cancer and 0.85 (0.77-0.94) for colorectal cancer.
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20473868 |
2011 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The evidence from our meta-analysis supports that TT genotype of MTHFR C677T polymorphism contributes to susceptibility to gastric cancer, but no significant association was detected for CC genotype of MTHFR A1298C.
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20470942 |
2010 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
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20957490 |
2010 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively.
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20504332 |
2010 |
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rs397507444
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0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis.
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20470942 |
2010 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Assuming a very low prior probability of 0.000001, similar to a probability assumed for a randomly selected single-nucleotide polymorphism in a genome-wide association study, and statistical power to detect an OR of 1.5, 4 associations were considered noteworthy as denoted by an FPRP value <0.2: GSTM1 null and bladder cancer (OR, 1.5; 95% CI, 1.3-1.6; P = 1.9 x 10(-14)), NAT2 slow acetylator and bladder cancer (OR, 1.46; 95% CI, 1.26-1.68; P = 2.5 x 10(-7)), MTHFR C677T and gastric cancer (OR, 1.52; 95% CI, 1.31-1.77; P = 4.9 x 10(-8)), and GSTM1 null and acute leukemia (OR, 1.20; 95% CI, 1.14-1.25; P = 8.6 x 10(-15)).
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18505952 |
2008 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C).
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18162478 |
2008 |
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rs397507444
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0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C).
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18162478 |
2008 |
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rs397507444
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0.100 |
GeneticVariation |
BEFREE |
No obvious association between the MTHFR A1298C polymorphism and the risk of stomach cancer was observed in this study.
|
17438654 |
2007 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
To clarify the influence of MTHFR C677T and A1298C polymorphisms on ga</span>stric cancer (GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried out.
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16758123 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
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16886608 |
2006 |