|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of our study was to (a) test for an association between the BDNF Val66Met polymorphism and childhood-onset melancholic depression and (b) to examine the interactive effects of stressful life events (SLE) and the Val66Met polymorphism on the risk of childhood-onset melancholic depression.
|
26462036 |
2015 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome.
|
23165919 |
2013 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, BDNF rs7103411 and rs6265 similarly predicted worse treatment response over 6 wk in clinical subtypes of depression such as melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 0.001).
|
19236730 |
2010 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of our study was to (a) test for an association between the BDNF Val66Met polymorphism and childhood-onset melancholic depression and (b) to examine the interactive effects of stressful life events (SLE) and the Val66Met polymorphism on the risk of childhood-onset melancholic depression.
|
26462036 |
2015 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome.
|
23165919 |
2013 |
|
rs6313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
About 62% of patients exhibiting the allelic combination of GG-GG-TT for rs6265, rs7430 and rs6313 of the BDNF, PPP3CC and HTR2A genes, respectively, and without melancholia showed a HAM-D decline under 17 compared to about 34% of the whole study sample.
|
25769916 |
2015 |
|
rs806371
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a higher frequency of rs806371 G carriers in MD patients with both presence of melancholia (p = 0.018) and psychotic symptoms (p = 0.007) than in controls.
|
23407780 |
2013 |
|
rs58532686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An additional -/CT insertion/deletion (ins/del) polymorphism (rs58532686), however, was significantly associated with melancholic depression, with a better response in 12 patients carrying the deletion.
|
20588071 |
2010 |
|
rs7103411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, BDNF rs7103411 and rs6265 similarly predicted worse treatment response over 6 wk in clinical subtypes of depression such as melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 0.001).
|
19236730 |
2010 |
|
rs25531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02).
|
18050262 |
2008 |
|
rs6295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |