| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.850 | GeneticVariation | BEFREE | Our meta-analysis suggests that the rs2104286 A allele is associated with increased MS risk in both Caucasians and Asians, whereas the rs12722489 C allele is associated with elevated MS risk in Caucasians but not in Asians. | 29648897 | 2018 |
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0.850 | GeneticVariation | BEFREE | The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Han and Hui nationalities. | 30352019 | 2018 |
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|
C | 0.850 | GeneticVariation | GWASDB | Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. | 22190364 | 2011 |
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|
C | 0.850 | GeneticVariation | GWASCAT | Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. | 22190364 | 2011 |
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|
0.850 | GeneticVariation | BEFREE | Using a fixed-effects model, the C allele and the CC genotype of the IL2RA rs12722489 polymorphism were found to be associated with MS but the CC + CT genotype was not. | 22117963 | 2011 |
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|
0.850 | GeneticVariation | BEFREE | Genome-wide association studies have identified an association between two intronic single nucleotide polymorphisms (SNPs), rs12722489 and rs2104286, in the interleukin-2 receptor alpha-chain gene (IL2RA) and susceptibility to multiple sclerosis (MS). | 21239413 | 2011 |
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|
0.850 | GeneticVariation | BEFREE | Here, we show that the IL2RA genotypes differentially affects soluble IL-2RA (sIL-2RA) levels in MS cases vs healthy controls; the two variants associated with MS (rs12722489 and rs2104286) account for 15 and 18% of the total variance in log(10)-transformed sIL-2RA concentration in control subjects but less so in subjects with MS (2 and 5%), suggesting that perturbations associated with disease or treatment may influence sIL-2RA levels in subjects with MS. | 19155502 | 2009 |
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|
C | 0.850 | GeneticVariation | GWASDB | Risk alleles for multiple sclerosis identified by a genomewide study. | 17660530 | 2007 |
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|
C | 0.850 | GeneticVariation | GWASCAT | Risk alleles for multiple sclerosis identified by a genomewide study. | 17660530 | 2007 |