Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of <i>PCSK9</i> (rs562556), <i>APOE</i> (epsilon polymorphism, rs7412 and rs429358), <i>LPL</i> (rs320), <i>MTHFR</i> (rs1801133), <i>eNOS</i> (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls. 29340220

2019

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE Thus, rs1333049 is associated with myocardial infarction in the white population of Western Siberia (Russia). 31330999

2019

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE Among an inception cohort of those who experienced MI </span>during follow-up, the risk allele of r</span>s1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2×10-3). 26950853

2016

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry. 26006241

2015

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE The current study demonstrates a strong association of the ANRIL SNP (rs1333049) with MI as well as familial hypercholesterolemia patients in a northern Pakistani population and could be used as a useful genetic marker for the screening of MI in the general Pakistani population. 23266621

2013

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction. 23787071

2013

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE In the case-control study, only haplotypes at 1 block tagged by rs1333049 associated with CAD more so than MI. 23729007

2013

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE Genome-wide significant associations with CAC for SNPs on chromosome 9p21 near CDKN2A and CDKN2B (top SNP: rs1333049; P=7.58×10(-19)) and 6p24 (top SNP: rs9349379, within the PHACTR1 gene; P=2.65×10(-11)) replicated for CAC and for MI. 22144573

2011

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE Specific polymorphisms (rs7865618, rs1537378, rs7857345, rs1333049) were identified as independent predictors of MI in multivariable models adjusted for conventional cardiovascular risk factors. 21511257

2011

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS. 20231156

2010

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE As proof of principle, we meta-analyzed risk variants at 9p21 and found that rs1333049 confers a 29% increase in risk for MI per copy (P=2×10⁻²⁰). 20923989

2010

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese. 19548844

2009

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms. 20031606

2009

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE Although the underlying mechanisms are not clearly understood, the previously reported association between the 2 SNPs (rs1333049 and rs17465637) and MI was reproduced in this Japanese sample. 18654002

2008

dbSNP: rs1333049
rs1333049
0.100 GeneticVariation BEFREE A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control studies involving a total of 4645 patients with myocardial infarction or CAD and 5177 controls.The mode of inheritance was determined. 18362232

2008