Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE While we confirmed the association of rs10757278 with CDKN2B expression in MI patients, we failed to find an association between the investigated variants and MI or disease burden. 31386834

2019

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE The aim of the study was to find whether patients carrying polymorphic allele of the rs10757278 polymorphism from 9p21 locus have changed risk of arrhythmia (atrial fibrillation, AF; sustained ventricular tachycardia or ventricular fibrillation, sVT/VF) during acute phase of myocardial infarction. 26615606

2016

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE We found even more significant association between rs</span>10757278 polymorphism and MI in pooled population, p = 3.55 × 10-53, after excluding the study from the Pakistan population. 26006241

2015

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE Genome-wide association studies have identified 2 single-nucleotide polymorphisms (SNPs) on chromosome arm 9p21, rs10757278, and rs2383207 that confer susceptibility to myocardial infarction. 23454037

2013

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE We replicated the association between the rs10757278 SNP and myocardial infarction and binary (presence/absence) angiographic classifications of CAD. 20729229

2010

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. 18459066

2009

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE We related SNPs rs2383207 and rs10757278 to stroke and to myocardial infarction and coronary revascularizations (coronary events) using crude and multivariate adjusted Cox proportional hazards models. 19293724

2009

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms. 20031606

2009

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest). 18505420

2008

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America. 18066490

2008

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America. 18048766

2008

dbSNP: rs10757278
rs10757278
0.900 GeneticVariation BEFREE Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI). 18925945

2008

dbSNP: rs10757278
rs10757278
G 0.900 GeneticVariation GWASCAT A common variant on chromosome 9p21 affects the risk of myocardial infarction. 17478679

2007

dbSNP: rs10757278
rs10757278
G 0.900 GeneticVariation GWASDB A common variant on chromosome 9p21 affects the risk of myocardial infarction. 17478679

2007

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease. 29894795

2018

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE The rs4977574 with G allele may confer to a higher risk of CAD, especially MI. 30278588

2018

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE We showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk. 26961926

2016

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI. 25738804

2015

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time. 24475106

2014

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification. 23561647

2013

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE PCR-RFLP revealed that the frequency of rs4977574, the MI-associated allele (G), was 56.8% (25/44) in patients with MI and 33.9% (9.5/28) in controls; the frequency of rs4977574 in patients with MI was significantly higher compared to controls (P = 0.027). 23856978

2013

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation BEFREE One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086). 22216278

2011

dbSNP: rs4977574
rs4977574
G 0.880 GeneticVariation GWASCAT Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. 19198609

2009

dbSNP: rs4977574
rs4977574
G 0.880 GeneticVariation GWASDB Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. 19198609

2009

dbSNP: rs4977574
rs4977574
0.880 GeneticVariation GWASDB A common variant on chromosome 9p21 affects the risk of myocardial infarction. 17478679

2007