|
rs1550094
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We also found evidence of association with spherical equivalent on 2q37.1 in PRSS56 at rs1550094 (MAF = 31%, β = -0.33, p = 1.7 × 10(-3)), a region previously associated with myopia.
|
27440996 |
2016 |
|
rs524952
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Moreover, 15q14 variant rs524952 (p=0.015, OR=1.49) also showed mild association with myopia and high myopia.
|
31604699 |
2019 |
|
rs7744813
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The SNP rs7744813, previously shown to be associated with refractive error and myopia in two GWAS, showed an odds ratio of 0.75 (95% CI 0.63-0.90; <i>P</i><sub>emp</sub> = 0.0058) for the minor allele.
|
28884119 |
2017 |
|
rs339501
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs339501
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The risk G allele of SNP rs339501 was associated with extreme myopia in human and caused a higher gene expression in the luciferase assay.
|
23599340 |
2013 |
|
rs339501
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Three FGF10 SNPs in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population, and the risk allele of rs339501 differed from the previous Chinese population.
|
24265547 |
2013 |
|
rs3759223
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Haplotype-specific tests showed that the C-C and T-C haplotypes were associated significantly with high myopia, with odds ratios (95% confidence intervals) of 19.32 (2.55-146.54) and 0.69 (0.46-1.04), respectively. rs3759223 and rs3741834 are in a putative regulatory element of the lumican gene, which influences fibrillogenesis of scleral collagen fibers and the development of myopia.
|
19616852 |
2009 |
|
rs3759223
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meta-analyses showed no association between rs3759223 polymorphism and high myopia susceptibility in all genetic models (CC vs. TT, OR = 1.089; 95% CI, 0.690 to 1.718; CT vs. TT, OR = 0.865; 95% CI, 0.646 to 1.157; CC + CT vs. TT, OR = 1.202; 95% CI, 0.730 to 1.980; CC vs. CT + TT, OR = 0.914; 95% CI, 0.771 to 1.083) and no significance in subgroup analyses according to the definition of high myopia (based on more myopic than -6.00 diopters vs. not based on more myopic than -6.00 diopters).
|
24927138 |
2014 |
|
rs3759223
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Pooled relative ratios (RRs) and 95% confidence interval (CI) were used to assess the strength of the associations between SNP rs3759223 and myopia.
|
24061151 |
2013 |
|
rs644242
|
|
|
0.030 |
GeneticVariation |
BEFREE |
SNPs rs644242 and rs662702 had marginal significance (P = 0.063), and further analyses showed that these SNPs were associated with extreme myopia (≤ -11 D).
|
21421876 |
2011 |
|
rs644242
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Five PAX6 SNPs, rs3026354, rs667773, rs2071754, rs644242, and rs3026393, were meta-analyzed in high myopia and two, rs667773 and rs644242, in extreme myopia.
|
24637479 |
2014 |
|
rs644242
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study provides additional evidence suggesting that the <i>PAX6</i> SNP rs644242 is associated with extreme myopia but not lower grade myopia.
|
29436400 |
2018 |
|
rs662702
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant differences were detected between the PAX6 gene (rs662702) TT and CT genotypes in moderate and high degree myopia; the risk C allele increased the risk for myopia.
|
30453065 |
2019 |
|
rs662702
|
|
|
0.030 |
GeneticVariation |
BEFREE |
SNPs rs644242 and rs662702</span> had marginal significance (P = 0.063), and further analyses showed that these SNPs were associated with extreme myopia (≤ -11 D).
|
21421876 |
2011 |
|
rs662702
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of four haplotype-tagging single-nucleotide polymorphisms (SNPs; rs2071754, rs3026354, rs3026390 and rs628224) and two previously reported SNPs (rs644242 and rs662702) in the <i>PAX6</i> gene were analysed in a Hong Kong Chinese cohort of 1288 myopia subjects (including 252 extreme myopia, 277 high myopia, 393 moderate myopia and 366 mild myopia) and 791 no myopia controls.
|
29436400 |
2018 |
|
rs10034228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotype and allele frequencies of the four SNPs showed significant differences between the myopia and control groups (rs2218817: genotype p = 0.009, OR = 1.18; rs10034228: genotype p = 0.009, OR = 1.18; rs1585471: genotype p = 0.007, OR = 1.19 and rs6837348: genotype p = 0.012, OR = 1.18).
|
22150588 |
2012 |
|
rs10034228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The 4q25 variant rs10034228 (p=0.002, OR=0.56) and <i>MIPEP</i> variant rs9318086 (p=0.004, OR=1.62) were found to be significantly associated with myopia as well as different severity of myopia.
|
31604699 |
2019 |
|
rs10453441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia.
|
25823570 |
2015 |
|
rs10453441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs13382811
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between either of these two SNPs alone and myopia did not replicate significantly in the combined cohorts of European descent, providing only suggestive results (<i>p</i><sub>allelic</sub> = 0.0088 for rs13382811 and <i>p</i><sub>allelic</sub> = 0.0319 for rs6469937).
|
28848321 |
2017 |
|
rs13382811
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
|
31300455 |
2019 |
|
rs577948
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the 11q24.1 genomic region, the rs11218544 polymorphism showed significant association with myopia [OR and 95% confidence interval (CI): 1.167 (1.032-1.319), p=0.013], while rs577948 showed no association with the disease [OR and 95%CI: 0.988 (0.727-1.342), p=0.936].
|
24672220 |
2014 |
|
rs577948
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We did not find evidence for the association of myopia with rs577948, rs11218544, or rs2839471 in the Chinese population studied.
|
22194655 |
2011 |
|
rs6214
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate the effect of the insulin-like growth factor-1 (IGF-1) gene's rs6214 and rs5742632 polymorphisms on IGF-1 expression levels and their association with different types of myopia in Egyptian patients.
|
27167306 |
2016 |
|
rs6214
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families.
|
21976954 |
2011 |