The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
The association between either of these two SNPs alone and myopia did not replicate significantly in the combined cohorts of European descent, providing only suggestive results (<i>p</i><sub>allelic</sub> = 0.0088 for rs13382811 and <i>p</i><sub>allelic</sub> = 0.0319 for rs6469937).