|
rs867114783
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One mutation each, involving a G-->T transversion in codon 215 in exon 6 (Ser-->lle) and a G-->A transition in codon 373 in exon 8 (Arg-->His), was identified in the remaining two secondary tumors.
|
10426802 |
1999 |
|
rs121912664
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the 19 patients with the Arg337His mutation, only one boy and three adults showed fatal evolution or recurrent metastases.
|
11600572 |
2001 |
|
rs121917887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Prune protein interacts with the metastasis suppressor nm23-H1, but shows impaired affinity towards the nm23-H1 S120G mutant associated with advanced neuroblastoma.
|
11687967 |
2001 |
|
rs137852578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth.
|
11956172 |
2002 |
|
rs864622007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth.
|
11956172 |
2002 |
|
rs523349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further studies of the V89L polymorphism may lead to better understanding of the etiology of prostate cancer metastases.
|
12042668 |
2002 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi.
|
12447372 |
2003 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi.
|
12447372 |
2003 |
|
rs121913403
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single strand conformation polymorphism and neucleotide sequencing analysis confirmed a TCT right curved arrow TTT somatic mutation at codon 37 changing serine to phenylalanine in one of the primary tumors and its corresponding metastatic tumor.
|
12632098 |
2003 |
|
rs75076352
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Individuals with the C634R mutation presented significantly more distant metastases at diagnosis than subjects with the C634Y or C634W mutations (54.5% vs. 19.4% vs. 14.3%, respectively, P = 0.03).
|
12788868 |
2003 |
|
rs75996173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with the C634R mutation presented significantly more distant metastases at diagnosis than subjects with the C634Y or C634W mutations (54.5% vs. 19.4% vs. 14.3%, respectively, P = 0.03).
|
12788868 |
2003 |
|
rs77709286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with the C634R mutation presented significantly more distant metastases at diagnosis than subjects with the C634Y or C634W mutations (54.5% vs. 19.4% vs. 14.3%, respectively, P = 0.03).
|
12788868 |
2003 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
None of the 30 metastases and 10 primary uveal melanomas tested expressed the V599E mutation.
|
14522889 |
2003 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
None of the 30 metastases and 10 primary uveal melanomas tested expressed the V599E mutation.
|
14522889 |
2003 |
|
rs121913227
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition, a double mutation resulting in V599K substitution was detected in two suspect ocular metastases of cutaneous melanoma.
|
14522889 |
2003 |
|
rs1284410244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT).
|
14525759 |
2004 |
|
rs765431049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT).
|
14525759 |
2004 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thirty-three samples (7 of 25 primaries, 15 of 25 regional metastases, 5 of 25 nodal metastases, and 6 of 10 distant metastases) harbored the V599E B-RAF mutation (39%), 12 contained a Q61R N-RAS mutation and 5 a Q61K N-RAS mutation.
|
14695143 |
2003 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thirty-three samples (7 of 25 primaries, 15 of 25 regional metastases, 5 of 25 nodal metastases, and 6 of 10 distant metastases) harbored the V599E B-RAF mutation (39%), 12 contained a Q61R N-RAS mutation and 5 a Q61K N-RAS mutation.
|
14695143 |
2003 |
|
rs5443
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that the GNB3 825C>T polymorphism does not appear to be associated with breast cancer risk, but may influence development of metastasis in low-grade tumors.
|
15019160 |
2004 |
|
rs761872690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the GNB3 825C>T polymorphism does not appear to be associated with breast cancer risk, but may influence development of metastasis in low-grade tumors.
|
15019160 |
2004 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF(V599E) tended to be associated, although not significantly, with a greater volume and extension of the tumour and with lymph-nodal metastases at surgery.
|
15272920 |
2004 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF(V599E) tended to be associated, although not significantly, with a greater volume and extension of the tumour and with lymph-nodal metastases at surgery.
|
15272920 |
2004 |
|
rs121917887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Compared with its wild-type, NDPK-A(S120G) appears more effective in promoting neuroblastoma metastasis.
|
15280446 |
2004 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Detection of B-raf exon 15 mutations or prediction of the activating mutation V599E were not statistically associated with the risk for subsequent metastasis in the follow-up of patients.
|
15331929 |
2004 |