rs944289
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, results of stratified analysis revealed that the risk effects of rs944289 and rs965513 were more overpowering in the subgroups of patients with MNG, as well as subjects without metastasis.
|
26356687 |
2015 |
rs944289
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016).
|
31681970 |
2019 |
rs10964862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification based on therapy showed that the adverse effect on metastasis development was statistically significant in the patients from Spain who did not receive any treatment and were homozygous for variant allele of rs10964862 (HR = 2.52, 95% CI 1.07-5.90; P = 0.03).
|
23209811 |
2012 |
rs116909374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016).
|
31681970 |
2019 |
rs12826786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, TT genotype of HOTAIR rs12826786 C>T polymorphism was significantly related with multiple clinicopathological characteristics concerned with worse BC progression such as advanced TNM stage (III and IV), larger tumor size (T3 and T4), and distant metastasis (M1), as well as poor histological grade (III) (P < 0.05).
|
26577852 |
2016 |
rs2555639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggested that the rs2555639 T allele is associated with increased risk of metastasis of colon cancer, which can be used as an indicator for colon cancer metastasis.
|
31646799 |
2020 |
rs2660852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three associations were located next to non-coding RNA genes. rs2660852 flanked 5'UTR of LTA4H (leukotriene A4 hydrolase), rs477145 was intronic to TIAM1 (T-cell lymphoma invasion and metastases) and rs2835931 was intronic to KCNJ6 (potassium channel, inwardly rectifying subfamily J, member 6).
|
26959888 |
2016 |
rs6475526
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariable survival analyses showed that the SNP rs6475526 (IFNA7/IFNA14) was associated with overall survival of the patients (P = 0.041 and event-free survival among patients without distant metastasis at the time of diagnosis, P = 0.034).
|
25350395 |
2014 |
rs7553007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CSS rates were low in the subgroup of patients with synchronous metastasis with the A-allele (A/A and A/G) at rs7553007 or mutated KRAS/BRAF in liver metastatic specimens.
|
23755178 |
2014 |
rs946486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele rs946486 in ABL had an OR of 1.5 (p-value = 0.01) for metastasis.
|
30827726 |
2019 |
rs8176746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients.
|
24941225 |
2014 |
rs514049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein.
|
30275760 |
2018 |
rs653765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein.
|
30275760 |
2018 |
rs768949233
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ADAM17-P729H mutation was shown to enhance cell migration, a phenotype associated with metastasis.
|
30627328 |
2018 |
rs1056123575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From this analysis, we show that the Cav-1(P132L) expression signature contains numerous genes that have been previously associated with cell migration, invasion, and metastasis.
|
19395651 |
2009 |
rs772893086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Preclinical studies with an in vivo xenograft mouse model also revealed that PCa cells with the IDH1 R132H mutation have more invasive metastasis.
|
31846689 |
2020 |
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant association of rs1800544 GG genotype with young age at diagnosis, premenopausal status, higher tumor size, metastasis in lymph nodes, advanced TNM stages and higher Nottingham Prognosis Indicator (NPI) (p < 0.05).
|
26563278 |
2016 |
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only the minor allele of rs2070600 was associated with a higher NLR (<i>β</i> = 0.209, <i>p</i> = 0.043) and a poor prognosis (Hazard ratio = 2.06, 95% Confidence interval = 1.09-3.77, <i>p</i> = 0.028) in patients with metastatic disease, independently of background characteristics, including EGFR mutation status.
|
29212235 |
2017 |
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The correlation between <i>AGER</i> polymorphisms (rs2070600, rs1800624, rs1800625) and disease susceptibility and factors elevating the mortality and NLR in patients with metastases were evaluated.
|
29212235 |
2017 |
rs1800625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The correlation between <i>AGER</i> polymorphisms (rs2070600, rs1800624, rs1800625) and disease susceptibility and factors elevating the mortality and NLR in patients with metastases were evaluated.
|
29212235 |
2017 |
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In two cohorts of patients with advanced metastatic disease, 98.0 % (n = 50) and 97.1 % (n = 35) concordance was obtained between tissue and blood samples for the AKT1 (E17K) mutation, and mutation capture rates of 66.7 % (2/3) and 85.7 % (6/7) in blood versus tissue samples were observed.
|
27515171 |
2016 |
rs2494752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, these results indicate that AKT1 rs2494752 polymorphisms may be regarded as a candidate gene in assessing the susceptibility, metastasis and responses to chemotherapy in the progression of hepatocellular carcinoma.
|
30127980 |
2018 |
rs1057519783
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In another case, EML4-ALK fusion detected in the primary tumor was associated with ALK G1202R secondary resistance mutation in the post-treatment metastasis.
|
30946933 |
2019 |
rs121913331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Arg1114X in APC gene, as a hot spot mutation in Chinese CRC, may predispose to the cancer metastasis of sporadic CRC.
|
17653897 |
2007 |
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
OS patients with allele G at rs1760944 were less susceptible to low differentiation tumor and metastasis (OR = 0.73, 95%CI 0.54-0.98; OR = 0.63, 95%CI 0.43-0.92, respectively).
|
28839218 |
2017 |