Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs944289
rs944289
0.020 GeneticVariation BEFREE Furthermore, results of stratified analysis revealed that the risk effects of rs944289 and rs965513 were more overpowering in the subgroups of patients with MNG, as well as subjects without metastasis. 26356687

2015

dbSNP: rs944289
rs944289
0.020 GeneticVariation BEFREE The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016). 31681970

2019

dbSNP: rs10964862
rs10964862
0.010 GeneticVariation BEFREE Stratification based on therapy showed that the adverse effect on metastasis development was statistically significant in the patients from Spain who did not receive any treatment and were homozygous for variant allele of rs10964862 (HR = 2.52, 95% CI 1.07-5.90; P = 0.03). 23209811

2012

dbSNP: rs116909374
rs116909374
0.010 GeneticVariation BEFREE The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016). 31681970

2019

dbSNP: rs12826786
rs12826786
0.010 GeneticVariation BEFREE Moreover, TT genotype of HOTAIR rs12826786 C>T polymorphism was significantly related with multiple clinicopathological characteristics concerned with worse BC progression such as advanced TNM stage (III and IV), larger tumor size (T3 and T4), and distant metastasis (M1), as well as poor histological grade (III) (P < 0.05). 26577852

2016

dbSNP: rs2555639
rs2555639
0.010 GeneticVariation BEFREE Our data suggested that the rs2555639 T allele is associated with increased risk of metastasis of colon cancer, which can be used as an indicator for colon cancer metastasis. 31646799

2020

dbSNP: rs2660852
rs2660852
0.010 GeneticVariation BEFREE Three associations were located next to non-coding RNA genes. rs2660852 flanked 5'UTR of LTA4H (leukotriene A4 hydrolase), rs477145 was intronic to TIAM1 (T-cell lymphoma invasion and metastases) and rs2835931 was intronic to KCNJ6 (potassium channel, inwardly rectifying subfamily J, member 6). 26959888

2016

dbSNP: rs6475526
rs6475526
0.010 GeneticVariation BEFREE Multivariable survival analyses showed that the SNP rs6475526 (IFNA7/IFNA14) was associated with overall survival of the patients (P = 0.041 and event-free survival among patients without distant metastasis at the time of diagnosis, P = 0.034). 25350395

2014

dbSNP: rs7553007
rs7553007
0.010 GeneticVariation BEFREE CSS rates were low in the subgroup of patients with synchronous metastasis with the A-allele (A/A and A/G) at rs7553007 or mutated KRAS/BRAF in liver metastatic specimens. 23755178

2014

dbSNP: rs946486
rs946486
0.010 GeneticVariation BEFREE The A allele rs946486 in ABL had an OR of 1.5 (p-value = 0.01) for metastasis. 30827726

2019

dbSNP: rs8176746
rs8176746
ABO
0.010 GeneticVariation BEFREE The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients. 24941225

2014

dbSNP: rs514049
rs514049
0.010 GeneticVariation BEFREE The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein. 30275760

2018

dbSNP: rs653765
rs653765
0.010 GeneticVariation BEFREE The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein. 30275760

2018

dbSNP: rs768949233
rs768949233
0.010 GeneticVariation BEFREE The ADAM17-P729H mutation was shown to enhance cell migration, a phenotype associated with metastasis. 30627328

2018

dbSNP: rs1056123575
rs1056123575
0.010 GeneticVariation BEFREE From this analysis, we show that the Cav-1(P132L) expression signature contains numerous genes that have been previously associated with cell migration, invasion, and metastasis. 19395651

2009

dbSNP: rs772893086
rs772893086
0.010 GeneticVariation BEFREE Preclinical studies with an in vivo xenograft mouse model also revealed that PCa cells with the IDH1 R132H mutation have more invasive metastasis. 31846689

2020

dbSNP: rs1800544
rs1800544
0.010 GeneticVariation BEFREE We found a significant association of rs1800544 GG genotype with young age at diagnosis, premenopausal status, higher tumor size, metastasis in lymph nodes, advanced TNM stages and higher Nottingham Prognosis Indicator (NPI) (p < 0.05). 26563278

2016

dbSNP: rs2070600
rs2070600
0.010 GeneticVariation BEFREE Only the minor allele of rs2070600 was associated with a higher NLR (<i>β</i> = 0.209, <i>p</i> = 0.043) and a poor prognosis (Hazard ratio = 2.06, 95% Confidence interval = 1.09-3.77, <i>p</i> = 0.028) in patients with metastatic disease, independently of background characteristics, including EGFR mutation status. 29212235

2017

dbSNP: rs1800624
rs1800624
0.010 GeneticVariation BEFREE The correlation between <i>AGER</i> polymorphisms (rs2070600, rs1800624, rs1800625) and disease susceptibility and factors elevating the mortality and NLR in patients with metastases were evaluated. 29212235

2017

dbSNP: rs1800625
rs1800625
0.010 GeneticVariation BEFREE The correlation between <i>AGER</i> polymorphisms (rs2070600, rs1800624, rs1800625) and disease susceptibility and factors elevating the mortality and NLR in patients with metastases were evaluated. 29212235

2017

dbSNP: rs121434592
rs121434592
0.010 GeneticVariation BEFREE In two cohorts of patients with advanced metastatic disease, 98.0 % (n = 50) and 97.1 % (n = 35) concordance was obtained between tissue and blood samples for the AKT1 (E17K) mutation, and mutation capture rates of 66.7 % (2/3) and 85.7 % (6/7) in blood versus tissue samples were observed. 27515171

2016

dbSNP: rs2494752
rs2494752
0.010 GeneticVariation BEFREE In conclusion, these results indicate that AKT1 rs2494752 polymorphisms may be regarded as a candidate gene in assessing the susceptibility, metastasis and responses to chemotherapy in the progression of hepatocellular carcinoma. 30127980

2018

dbSNP: rs1057519783
rs1057519783
ALK
0.010 GeneticVariation BEFREE In another case, EML4-ALK fusion detected in the primary tumor was associated with ALK G1202R secondary resistance mutation in the post-treatment metastasis. 30946933

2019

dbSNP: rs121913331
rs121913331
APC
0.010 GeneticVariation BEFREE Arg1114X in APC gene, as a hot spot mutation in Chinese CRC, may predispose to the cancer metastasis of sporadic CRC. 17653897

2007

dbSNP: rs1760944
rs1760944
0.010 GeneticVariation BEFREE OS patients with allele G at rs1760944 were less susceptible to low differentiation tumor and metastasis (OR = 0.73, 95%CI 0.54-0.98; OR = 0.63, 95%CI 0.43-0.92, respectively). 28839218

2017