Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434569
rs121434569
0.040 GeneticVariation BEFREE The T790M resistance mutation was detected in metastases in 3 patients with acquired resistance to EGFR tyrosine kinase inhibitors. 26968843

2016

dbSNP: rs121434569
rs121434569
0.040 GeneticVariation BEFREE A concomitant squamous histology transformation in a lung non-T790M-resistant metastasis is also described. 24029120

2014

dbSNP: rs121434569
rs121434569
0.040 GeneticVariation BEFREE : Our results imply that blockade of the TGF-β signaling pathway combined with continuous EGFR TKI treatment will be beneficial in preventing metastasis in patients with EGFR TKI-resistant NSCLC without the EGFR T790M resistance mutation. 23334091

2013

dbSNP: rs121434569
rs121434569
0.040 GeneticVariation BEFREE In an autopsy case, the T790M mutation was found in multiple visceral metastases but not in a brain lesion. 17085664

2007

dbSNP: rs723526
rs723526
0.010 GeneticVariation BEFREE Furthermore, in a meta-analysis, 3 additional SNPs were significantly associated with SLN metastasis (EGFR rs723526 and TLR3 rs3775292) and melanoma-specific death (TLR3 rs7668666). 23462921

2013

dbSNP: rs121434568
rs121434568
0.010 GeneticVariation BEFREE Eligible participants were adults (> 18 years) with NSCLC and EGFR mutations (exon 19 deletion or L858R mutation in exon 21) with no history of chemotherapy for metastatic disease (neoadjuvant or adjuvant chemotherapy ending ≥ 6 months before study entry was allowed). 22285168

2012