|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers.
|
29222906 |
2019 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we report on 3 men with hyperhomocysteinemia and the MTHFR C677T homozygous TT genotype that have reproductive histories of fetal NTDs.
|
30633186 |
2019 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T, but not A1298C, was associated with neural tube defects (OR, 1.24; 95% CI, 1.08-1.42) and Down syndrome (OR, 1.65; 95% CI, 1.39-1.95).
|
30474229 |
2019 |
|
rs1801394
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For MTHFD1 rs2236225 polymorphism, mothers having GA genotype and A allele exhibited an increased risk of NTDs in the offspring (OR = 2.600, 95%CI: 1.227-5.529; OR = 1.847, 95%CI: 1.047-3.259).
|
30867013 |
2019 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T, but not A1298C, was associated with neural tube defects (OR, 1.24; 95% CI, 1.08-1.42) and Down syndrome (OR, 1.65; 95% CI, 1.39-1.95).
|
30474229 |
2019 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
|
rs1801394
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that rs2236225 of MTHFD1 gene, rs1801133 of MTHFR gene and rs1801394 of MTRR gene were associated with NTDs in Han population of Northern China.
|
29392422 |
2018 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For rs2236225 within MTHFD1, children with allele A or genotype AA had a high NTDs risk (OR=1.500, 95%CI=1.061~2.120; OR=2.862, 95%CI=1.022~8.015, respectively).
|
29392422 |
2018 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our research provides the first evidence supporting a paternal, rather than a maternal, transmission bias of MTHFD1 G1958A variant for NTD susceptibility in the offspring.
|
26394717 |
2016 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the A1298C polymorphism cannot be regarded as a major risk factor for NTDs.
|
27323133 |
2016 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects.
|
25788000 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no association between any of the fathers' genotypes and NTDs, whereas a significant correlation between MTHFR C677T polymorphism and NTD risk was found in NTD patients and in their mother.
|
25808073 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed that the SNPs of 677C > T and 1298A > C in MTHFR were associated with NTD-affected pregnancy, in which 677C > T was a risk factor and in contrast 1298A > C was protective factor against NTD.
|
25855017 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interaction of COMT rs737865 and MTHFR C677T was associated with an increased risk of NTDs, especially anencephaly, in a Chinese population with a high prevalence of NTDs.
|
24990354 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, in stratified analysis by geographical regions, we found that the maternal C677T polymorphism was significantly associated with the risk of NTD in Asian (OR(TvsC) = 1.43; 95% CI: 1.05-1.94), European (OR(TvsC) = 1.13; 95% CI: 1.04-1.24) and American (OR(TvsC) = 1.26; 95% CI: 1.13-1.41) populations.
|
25005003 |
2015 |
|
rs1801394
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, we found that maternal MTHFR C677T polymorphism (OR(TvsC) =1.20; 95% CI = 1.13-1.28) and MTRR A66G polymorphism (OR(GvsA) = 1.21; 95% CI = 0.98-1.49) were risk factors for producing offspring with NTD but maternal MTHFR A1298C polymorphism (OR(CvsA) = 0.91; 95% CI = 0.78-1.07) was not associated with NTD risk.
|
25005003 |
2015 |
|
rs1801394
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The further meta-analysis enhance that MTRR 66A>G was connected with the susceptibility of NTDs widely.
|
26334892 |
2015 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The haplotype GGGG, which consists of 4 SNPs (rs2236225, rs2236224, rs1256146, and rs6573559), is also associated with risk of NTDs (P value=0.0438, OR=0.7180, 95% CI=0.5214-0.9888).
|
26343515 |
2015 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, there was no significant association between the MTHFD1 G1958A polymorphism in NTD patients and the risk of NTD.
|
25502174 |
2015 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analysis implicated that MTHFD1 1958G>A was significantly associated with the susceptibility of NTD in a Chinese population.
|
25524527 |
2015 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the 1298 A > C polymorphism was shown to lower the risk of NTD-affected pregnancy.
|
25855017 |
2015 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, we found that maternal MTHFR C677T polymorphism (OR(TvsC) =1.20; 95% CI = 1.13-1.28) and MTRR A66G polymorphism (OR(GvsA) = 1.21; 95% CI = 0.98-1.49) were risk factors for producing offspring with NTD but maternal MTHFR A1298C polymorphism (OR(CvsA) = 0.91; 95% CI = 0.78-1.07) was not associated with NTD risk.
|
25005003 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C677T mutation in methylenetetrahydrofolate reductase gene and neural tube defects: should Japanese women undergo gene screening before pregnancy?
|
24588777 |
2014 |