|
rs10010131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |
|
rs10082248
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs10082248, rs2298930 and rs4545339 were associated with the risk of obesity in the recessive model (P < 0.05, respectively).
|
24729284 |
2014 |
|
rs10146997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor G-allele of rs10146997 in NRXN3 associated with increased WC among women (β = 0.55cm (0.20;0.89), p(additive) = 1.7×10(-3), p(interaction) = 1.0×10(-3)), but showed no associations with obesity related metabolic traits.
|
21674055 |
2011 |
|
rs1014959895
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs10182181
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs10182181
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs10189761
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs10189761
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs1021001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three polymorphisms, rs12186500 (odds ratio (OR): 1.892, 95% confidence interval (CI): 1.237-2.895, P=0.003), rs1021001 (OR: 2.102, 95% CI: 1.280-3.455, P=0.003) and rs4285184 (OR: 1.587, 95% CI: 1.024-2.459, P=0.038) were associated with a higher prevalence of obesity among the adult men and a trend for obesity was observed for rs4285184 among the Swedish (OR: 1.205, 95% CI: 0.987-1.471, P=0.067) and Greek children (OR: 1.192, 95%CI: 0.978-1.454, P=0.081).
|
21304485 |
2012 |
|
rs10246939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, <i>TAS2R38</i> rs10246939 variation was associated with Koreans' dietary intake and increased their risk of obesity.
|
31438650 |
2019 |
|
rs1026520
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Coincidentally, the haplotype containing the rs1026520-C and rs9794-C alleles was also associated with a statistically decreased risk of abdominal obesity after covariate adjustment (OR = 0.59, 95% CI = 0.45-0.77, p < 0.001).
|
26073637 |
2016 |
|
rs1040070
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association meta-analysis identifies new childhood obesity loci.
|
22484627 |
2012 |
|
rs10401969
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of hepatic lipid content in extreme obesity.
|
25246029 |
2015 |
|
rs10418248
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, no association was found between obesity and the previously described -800T>A SNP (rs10418248).
|
19189687 |
2008 |
|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant associations were observed between the SULT1A1 genotype (Arg213His) and age, obesity and certain neoplasias (mammary, pulmonary, esophageal and urothelial cancer).
|
14600802 |
2004 |
|
rs10423928
|
|
T |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs10423928
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have selected three <i>p53</i> polymorphisms, rs1642785 (C > G), and rs9894946 (A > G), and rs1042522 (Pro72Arg; C > G) and assessed their association with obesity risk in the Saudi population.
|
31762593 |
2019 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.
|
26947067 |
2016 |
|
rs1042571
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The common variant rs1042571 in the 3'UTR was significantly associated with BMI in EAs (Overweight: P(adj) = 0.005; Obese: P(adj) = 0.018; Overweight+Obese: P(adj) = 0.002) but not in AAs.
|
23028917 |
2012 |
|
rs1042571
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
|
26226973 |
2016 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, our results do not support an association between rs1042713 (Arg16Gly) polymorphisms and obesity in the populations investigated.
|
24960039 |
2014 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors.
|
22094842 |
2011 |
|
rs1042713
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |