rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.
|
25074273 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women.
|
24307561 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.
|
24151814 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.
|
25501231 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children.
|
24139164 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals.
|
24385306 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |
rs1421085
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
rs1421085
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
rs1421085
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05).
|
23342142 |
2013 |
rs1421085
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity.
|
23849767 |
2013 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of 11 studied SNPs, four SNPs and genetic risk score (GRS) based on them were statistically significantly associated with central obesity by WC criteria (FTO rs9939609: OR = 1.29, 95%CI = 1.10-1.50, p = 0.001; MC4R rs17782313: OR = 1.27, 95%CI = 1.12-1.44, p = 1.32×10⁻⁴; GNPDA2 rs10938397: OR = 1.22, 95%CI = 1.09-1.37, p = 4.09×10⁻⁴; BDNF rs6265: OR = 1.20, 95%CI = 1.08-1.34, p = 8.86×10⁻⁴; GRS: OR = 1.25, 95%CI 1.16-1.34, p = 2.58×10⁻⁹) after adjustment for sex, age, pubertal stage, physical activity and family history of obesity.
|
23424664 |
2013 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
|
23447422 |
2013 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)-an effect that persisted after adjustment for body weight (P = 0.004).
|
22513296 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001).
|
22350153 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans.
|
22869321 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02).
|
22511254 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p<0.001).
|
23049848 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children.
|
23091647 |
2012 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population.
|
21814223 |
2011 |
rs1421085
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
|
21935397 |
2011 |