rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively.
|
31502573 |
2019 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.
|
31350533 |
2019 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure.
|
28579220 |
2018 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Impact of the Polymorphism Near <i>MC4R</i> (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program.
|
28828082 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity.
|
27730429 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
<i>Purpose</i>.Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (<i>MC4R</i>) gene and rs6265 near the brain-derived neurotrophic factor (<i>BDNF</i>) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children.
|
28396685 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
|
28090739 |
2017 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
|
26948330 |
2016 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
|
26226973 |
2016 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings indicated that rs17782313, rs543874, rs2241423 and rs11084753 were associated with the risk for children obesity in China, and interaction of genetic variants with diet behaviors on obesity.
|
25637721 |
2015 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs9939609 and rs17782313 are associated with PCOS and obesity-related traits and profiles.
|
26032905 |
2015 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women.
|
24307561 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.
|
24151814 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.
|
25501231 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children.
|
24139164 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals.
|
24385306 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity.
|
23849767 |
2013 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of 11 studied SNPs, four SNPs and genetic risk score (GRS) based on them were statistically significantly associated with central obesity by WC criteria (FTO rs9939609: OR = 1.29, 95%CI = 1.10-1.50, p = 0.001; MC4R rs17782313: OR = 1.27, 95%CI = 1.12-1.44, p = 1.32×10⁻⁴; GNPDA2 rs10938397: OR = 1.22, 95%CI = 1.09-1.37, p = 4.09×10⁻⁴; BDNF rs6265: OR = 1.20, 95%CI = 1.08-1.34, p = 8.86×10⁻⁴; GRS: OR = 1.25, 95%CI 1.16-1.34, p = 2.58×10⁻⁹) after adjustment for sex, age, pubertal stage, physical activity and family history of obesity.
|
23424664 |
2013 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
|
23447422 |
2013 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001).
|
22350153 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans.
|
22869321 |
2012 |
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02).
|
22511254 |
2012 |