Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1064794292
rs1064794292
0.700 GeneticVariation UNIPROT

dbSNP: rs121913385
rs121913385
0.700 GeneticVariation UNIPROT

dbSNP: rs1444669684
rs1444669684
0.030 GeneticVariation BEFREE We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors. 26408346

2016

dbSNP: rs1444669684
rs1444669684
0.030 GeneticVariation BEFREE In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival. 23980075

2013

dbSNP: rs1444669684
rs1444669684
0.030 GeneticVariation BEFREE We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas. 17349581

2007